Abstract: With the continuous improvement of endoscopic technology and equipment,minimally invasive treatment of bile duct stones becomes increasingly diversified.In this paper,the concept of minimally invasive treatment of bile duct stones,surgical indications and contraindications,surgical methods,and the advantages and disadvantages of surgical methods are introduced.It is shown that the application of laparoscope has laid the foundation for the minimally invasive treatment of bile duct stones,and the combined application of choledochoscope and endoscope has brought new ideas for minimally invasive treatment of bile duct stones.The combination of three endoscopes avoids the disadvantages of traditional open surgery: large trauma and long operation time,and reduces the patient' s pain and complications.In the near future,the combination of three endoscopes still has much room for growth.As long as the indications for several surgeries are mastered and the safety and efficacy are evaluated objectively,the combination of three endoscopes will play the biggest role.