Abstract: Objective To investigate plain and dynamic enhanced magnetic resonance imaging(MRI) and computed tomography(CT)findings in patients with focal nodular hyperplasia(FNH) of the liver and hepatocellular carcinoma(HCC) patients with negative alpha-fetoprotein(AFP).Methods A statistical analysis was performed on the clinical data of 124 cases of liver tumor admitted to Beijing Miyun County Hospital from April 2012 to April 2014.Results Fifty-five of the 74 patients with FNH underwent CT examination,among whom38 patients received three-phase dynamic enhanced scan and 16 received only plain scan; 62 cases had plain and enhanced MRI with the application of contrast agent Gd-BOPTA in 42 patients.Among the 50 HCC patients with negative AFP,CT examination was performed in40 and 10 only had plain scan; 46 patients received plain and enhanced MRI with the use of contrast agent Gd-BOPTA in 30.Delayed scan after 1-2 h demonstrated low signal in 30 lesions of the 30 cases.Conclusion For patients with liver FNH and AFP-negative HCC patients,their plain and dynamic enhanced MRI and CT scan have respective characteristics.A combination of multiple examination methods can significantly improve diagnostic yield of the two diseases.