Abstract: Objective To explore the value of endoscopic retrograde cholangiopancreatography(ERCP) in the treatment of chronic pancreatitis(CP).Methods Thirty patients with CP who underwent ERCP from January 2008 to December 2012 were retrospectively analyzed.Serum amylase levels were determined before and at 24 hours after surgery.The reduction in abdominal pain was dynamically evaluated before and after treatment.A follow-up of patients with steatorrhea and anxiety was performed.Regular reexamination using abdominal imaging or ERCP was performed to identify pancreatic lesions and conditions of pancreatic duct stents.Results All patients were successfully treated by ERCP and had pancreatic duct stents placed.The remission rate of abdominal pain reached 83.3% at 72 hours after surgery.One patient was assigned to surgery due to insignificant improvement in symptoms,and the case-fatality rate after surgery was 0.Conclusion ERCP is an effective method in the treatment of CP,which has the advantages of being safe,effective,and minimally invasive.