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Signal transduction involved in activation of hepatic stellate cells
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摘要: 肝星状细胞(HSC)是肝脏的主要纤维生成细胞,其活化增殖,进而产生大量细胞外基质,是肝纤维化形成的中心环节。随着对肝纤维化的深入研究,HSC活化过程中所涉及的信号转导已成为研究热点。归纳了HSC活化过程中所涉及的主要信号转导,并介绍了近年来的相关研究进展。相信随着对这些信号转导的深入研究,肝纤维化的防治必将取得新突破。Abstract: Hepatic stellate cells( HSCs) are the source of fibre in the liver which can produce a large number of extracellular matrix via proliferation and activation,and this is the central link of hepatic fibrosis. Following further research on hepatic fibrosis,signal transduction involved in the activation of HSCs have been researched as a popular topic. This paper generalizes the main signaling transduction pathways involved in activation of HSCs and Hedgehog / Gli pathway,and introduces recent advances in related research. It is promising to make new breakthroughs in the prevention and treatment of hepatic fibrosis through in- depth study of these signaling pathways.
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Key words:
- liver cirrhosis /
- hepatic stellate cells /
- activation /
- signal transduction /
- review
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