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Autoimmune sclerosing cholangitis: new concept and new evidence
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摘要:
硬化性胆管炎根据其病因及发病机制不同可分为原发性硬化性胆管炎(PSC)和继发性硬化性胆管炎,其中PSC的发病可能与免疫相关。近些年,新发现了一种硬化性胆管炎,以血清及组织免疫球蛋白(Ig)G4水平升高为特征,对激素治疗效果良好。PSC和Ig G4相关硬化性胆管炎可统称为自身免疫性硬化性胆管炎,在新概念中探索多种表现为硬化性胆管炎疾病间的同与异,更有助于拓展免疫相关性疾病的新思路与方向。
Abstract:Sclerosing cholangitis can be divided into primary sclerosing cholangitis( PSC) and secondary sclerosing cholangitis according to the etiology and pathogenesis,and the pathogenesis of PSC may be associated with immunity. In recent years,a new type of sclerosing cholangitis has been found,which is characteristic of elevated levels of Ig G4 in serum and tissue and good response to steroid therapy. PSC and Ig G4- related sclerosing cholangitis can be collectively referred to as autoimmune sclerosing cholangitis. This article explores the similarities and differences between various diseases with manifestations of sclerosing cholangitis in the new concept,which will provide new ideas and directions for immune- related diseases.
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Key words:
- cholangitits,sclerosing /
- autoimmune diseases /
- immunoglobulin G
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