Progress and prospect of diagnosis and treatment of hepatic fibrosis by integrated traditional Chinese and Western medicine therapy
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摘要:
近年来肝纤维化的无创性诊断技术和方法日益受到重视,介绍了血清标志物、瞬时弹性成像技术(Fibro Scan)等非创伤性诊断技术在肝纤维诊断中的应用。抗肝纤维化治疗应是包括病因治疗、抗炎保肝、抑制细胞外基质合成和降解过多沉积的细胞外基质为一体的系统治疗。对于慢性病毒性肝炎所致的肝纤维化,抗病毒治疗是抗肝纤维化的基础,而中医药在抑制合成及降解过多沉积的以胶原为主的细胞外基质方面,具有作用于多个环节、多个层次和多个靶点的特性,而成为肝纤维化治疗的新希望。但是,中西医结合抗肝纤维化的优势仍需通过设计严谨、多中心、大样本的临床研究以提供循证医学证据支持,而深入研究中医药抗肝纤维化作用机制也是今后的重要任务之一。
Abstract:In recent years,non-invasive methods for assessment of hepatic fibrosis have attracted more and more attention,and the application of non-invasive diagnostic techniques such as serum markers and transient elastography(Fibro Scan) for hepatic fibrosis is reviewed.Anti-fibrosis treatments should integrate etiological treatment,anti-inflammatory and liver-protecting therapy,and inhibiting the synthesis of extracellular matrix and degrading excessively deposited extracellular matrix.Antiviral treatment is the basis for resisting hepatic fibrosis due to chronic viral hepatitis.In this aspect,traditional Chinese medicine(TCM) has advantages in inhibiting the synthesis of extracellular matrix and degrading excessively deposited extracellular matrix,because it effects on multiple links,at multiple levels,and against multiple targets.So integrated traditional Chinese and Western medicine therapy is a promising treatment strategy.However,the benefit of integrative therapy against hepatic fibrosis still needs to be supported by rigorously designed,multicenter,large-sample clinical studies,and the mechanism of anti-fibrosis TCM treatment deserves further studies.
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Key words:
- liver cirrhosis /
- TCM WM therapy /
- diagnosis /
- therapy
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