新疆地区HBV基因型分布特点及其与肝硬化的相关性分析

王晓忠; 王燕; 马燕; 郭峰; 庄小芳

doi:10.3969/j.issn.1001-5256.2014.12.018

新疆地区HBV基因型分布特点及其与肝硬化的相关性分析

DOI: 10.3969/j.issn.1001-5256.2014.12.018

新疆维吾尔自治区中医医院肝病科

基金项目:

新疆维吾尔自治区自然科学基金项目(20123314619)；

详细信息

中图分类号: R512.62;R575.2
计量
- 文章访问数: 2354
- HTML全文浏览量: 18
- PDF下载量: 583
- 被引次数: 0
出版历程
- 收稿日期: 2014-03-24
- 出版日期: 2014-12-20

Analysis of HBV genotype distribution and its association with liver cirrhosis in Xinjiang Uygur Autonomous Region, China

Department of Liver Diseases, Traditional Chinese Medical Hospital of Xinjiang Uygur Autonomous Region

Research funding:

摘要

摘要: 目的探讨新疆地区HBV基因分型构成特点及其与肝硬化之间的关系。方法收集2011年10月至2013年6月新疆维吾尔自治区中医医院收治的慢性HBV感染者1018例。其中检测出基因型、资料完整的828例。根据实验室检查及彩超或CT结果将患者分为慢性乙型肝炎组、肝硬化组、原发性肝癌组。采用PCR法对HBV基因分型,运用列联卡方、秩和检验、多因素Logistic回归分析等方法对HBV基因型与临床病情及相关慢性肝病结局进行分析。结果 828例患者中,以C型为主,占总样本的54.11%(448/828),B型占25.15%(200/828),D型占16.18%(134/828);各基因型病情程度构成差异无统计学意义(H=0.1689,P>0.05);116例肝硬化患者中基因C型占20.84%,与B型和D型相比较差异均有统计学意义(χ2值分别为25.486、20.947,P值均为0.000);乙型肝炎病程10年以上、基因C型、HBV DNA高病毒载量、ALT>ULN进入回归模型(P<0.05)。其中基因C型与肝硬化的相关度最高(OR=2.819,95%CI:1.582~5.021)。...
- 肝炎,乙型,慢性 /
- 基因型 /
- 肝硬化
Abstract: Objective To investigate the distribution of hepatitis B virus (HBV) genotypes among patients in Xinjiang Uygur Autonomous Region, China, and to explore its association with liver cirrhosis. Methods HBV genotypes of 1018 hepatitis B patients were determined by PCR analysis. The relationship of HBV genotype with clinical outcomes and relevant chronic liver diseases was assessed by contingency chi-square test, Kruskal-Wallis test, and multivariate unconditional logistic regression analysis. Results Among the 828 patients whose HBV genotyping was completed in this study, type C was the major genotype and the percentage was 54. 11% (448 /828) , 25. 15% (200 /828) had type B, and 16. 18% (134 /828) had type D. Among the 116 patients with liver cirrhosis, 20. 84% had type C, which was significantly more frequent than other genotypes (P < 0. 00) . The multivariate unconditional logistic regression model identified several risk factors for liver cirrhosis, including duration of hepatitis B≥10 years, C genotype, high HBV DNA viral load, and impaired liver function characterized by abnormal alanine aminotransferase test. Among all these factors, genotype C had the highest relevance to liver cirrhosis (OR =2. 819, 95% CI: 1. 582-5. 021) . Conclusion The leading genotype of HBV in Xinjiang Uygur Autonomous Region is type C, followed by type B and type D. Genotype C is an independent risk factor for HBV-related liver cirrhosis.
- hepatitis B, chronic /
- genotype /
- liver cirrhosis

HTML全文

参考文献(10)

[1]SHI YH.Correlation between hepatitis B virus genotypes and clinical outcomes[J].Jpn J Infect Dis, 2012, 65 (6) :476-482.

[2] Chinese Society of Hepatology and Chinese Society of Infectious Diseases, Chinese Medical Association.The guideline of prevention and treatment for chronic hepatitis B (2010 version) [J].Chin J Hepatol, 2011, 19 (1) :13-24. (in Chinese) 中华医学会肝病学分会, 中华医学会感染病学分会.慢性乙型肝炎防治指南 (2010年版) [J].中华肝脏病杂志, 2011, 19 (1) :13-24.

[3]Chinese Society of Infectious Diseases and Parasitology and Chinese Society of Hepatology of Chinese Medical Association.The programme of prevention and cure for viral hepatitis[J].Chin J Infect Dis, 2001, 19 (1) :56-62. (in Chinese) 中华医学会传染病与寄生虫病学分会, 肝病学分会.病毒性肝炎防治方案[J].中华传染病杂志, 2001, 19 (1) :56-62.

[4]XU H, ZHANG YX, WEI L, et al.Relationship between the genotypes of hepatitis B virus and clinical courses in groups of the Han nationality in Xinjiang[J].J Pract Hepatol, 2005, 8 (1) :11-15. (in Chinese) 徐红, 张跃新, 魏来, 等.新疆汉族人群HBV基因型与临床病情的关系[J].实用肝脏病杂志, 2005, 8 (1) :11-15.

[5]LU XB, WANG XL, DENG GH, et al.Distribution and characteristics of hepatitis B virus genotypes in Uighur patients with chronic hepatitis B in Xinjiang province of China[J].Chin J Hepatol, 2007, 15 (4) :241-244. (in Chinese) 鲁晓擘, 王晓岚, 邓国宏, 等.新疆维吾尔族慢性乙型肝炎患者HBV基因型分布及其特点[J].中华肝脏病杂志, 2007, 15 (4) :241-244.

[6]LI CD, WU B, DUAN ZJ, et al.Investigation of relationship between hepatitis B virus genotyping and HBV-DNA level and serologic markers[J].Chin J Nosocomiol, 2012, 22 (5) :907-909. (in Chinese) 李彩东, 吴斌, 段正军, 等.乙型肝炎病毒基因分型与HBVDNA水平及血清标志物关系的探讨[J].中华医院感染学杂志, 2012, 22 (5) :907-909.

[7]MAO JZ, ZHANG J, LIU GY, et al.HBV genotypes and P gene point mutation in different stages of HBV infection and their significance[J].Chin J Clin Lab Sci, 2012, 30 (8) :586-588. (in Chinese) 毛菊珍, 张静, 刘广印, 等.HBV感染不同时期基因分型和P基因区点突变及其意义[J].临床检验杂志, 2012, 30 (8) :586-588.

[8]YIN JH, ZHAO J, ZHANG HW, et al.HBV genotype C is independently associated with cirrhosis in community-based population[J].World J Gastroenterol, 2010, 16 (3) :379-383.

[9]CHAN HL, WONG GL, TSE CH, et al.Hepatitis B virus genotype C is associated with more severe liver fibrosis than genotype B[J].Clin Gastroenterol Hepatol, 2009, 7 (12) :1361-1366.

[10]YANG JH, CHEN G, ZHANG H, et al.Distribution of HBV genotypes and clinical characteristics of HBV-related hepatocellular carcinoma patiens in Deyang District, Sichuan Province[J].Chin J Hepatol, 2013, 21 (6) :473-474. (in Chinese) 杨家红, 陈皋, 张浩, 等.四川省德阳地区乙型肝炎病毒相关性肝癌患者的病毒基因型分布及其临床特点[J].中华肝脏病杂志, 2013, 21 (6) :473-474.

施引文献

资源附件(0)

访问统计