甘肃地区汉族和回族慢性乙型肝炎患者雌激素受体α-29位基因多态性分析

周宁; 张月荣; 魏世芳; 吴丽阳; 李象霖

doi:10.3969/j.issn.1001-5256.2014.12.017

甘肃地区汉族和回族慢性乙型肝炎患者雌激素受体α-29位基因多态性分析

DOI: 10.3969/j.issn.1001-5256.2014.12.017

兰州市第一人民医院感染科

详细信息

中图分类号: R512.62
计量
- 文章访问数: 2840
- HTML全文浏览量: 16
- PDF下载量: 484
- 被引次数: 0
出版历程
- 收稿日期: 2014-03-17
- 出版日期: 2014-12-20

Analysis of ERα-29 polymorphisms between Han nationality and Hui minority populations with chronic hepatitis B in Gansu Province, China

Department of Infectious Diseases, The First People 's Hospital of Lanzhou

摘要

摘要: 目的分析甘肃地区汉族和回族慢性乙型肝炎（CHB）患者雌激素受体（ER）α-29位基因多态性的分布情况。方法选取2012年8月至2013年11月在兰州市第一人民医院就诊的甘肃地区回族及汉族CHB患者各84例。采用聚合酶链反应-限制性片段长度多态性法检测ERα-29位多态性。用基因计数法计算检验人群的等位基因频率,进行Hardy-Weinberg遗传平衡定律检验。应用非条件Logistic回归分析将混杂因素进行调整。基因型及等位基因频率比较采用卡方检验。结果甘肃省汉族、回族CHB人群的ERα-29位点基因型频率:TT为52.4%、60.7%;TC为40.5%、34.5%;CC为7.1%、4.8%。等位基因频率:T为72.6%、78.0%;C为27.4%、22.0%。ERα-29位基因型频率在甘肃汉族、回族CHB患者间的差异无统计学意义（P>0.05）。结论ERα-29位基因多态性在甘肃省汉族、回族CHB人群中无民族差异。
- 肝炎,乙型,慢性 /
- 雌激素受体α /
- 多态性,单核苷酸 /
- 甘肃 /
- 汉族 /
- 回族
Abstract: Objective To investigate the genetic polymorphisms in the estrogen receptor (ER) alpha gene at position 29 (ERα-29) in patients with chronic hepatitis B (CHB) from Han nationality and Hui minority populations in Gansu Province, China. Methods Polymorphisms of ERα-29 were analyzed in 84 Han and 84 Hui CHB patients who were admitted to our hospital from August 2012 to November 2013 by polymerase chain reaction-restriction fragment length polymorphism analysis. Allele frequencies were determined by gene counting and tested for expectations of Hardy-Weinberg equilibrium. Unconditional logistic regression analysis was applied to adjust the confounding factors. Comparison of the genotype and allele frequencies was performed by chi-square test. Results The genotype frequencies of ERα-29 in Han versus Hui CHB patients from Gansu Province were as follows: TT, 52. 4% vs 60. 7%; TC, 40. 5% vs 34. 5%; CC, 7. 1% vs 4. 8%. The allele frequencies were 72. 6% vs 78. 0% for the T allele and 27. 4% vs 22. 0% for the C allele. No significant differences in the allele and genotype frequencies of ERα-29 were found between Han and Hui CHB patients in Gansu Province (P > 0. 05) . Conclusion The genetic polymorphisms in ERα-29 are not significantly different between Han and Hui CHB patients in Gansu Province, China.
- hepatitis B, chronic /
- estrogen receptor alpha /
- polymorphism, single nucleotide /
- GANSU /
- HAN NATIONALITY /
- HUI NATIONALITY

HTML全文

参考文献(12)

[1]SCHUIT SC, JONG FH, STOLK L, et al.Estrogen receptor alpha gene-polymorphisms are associated with estradiol levels in postmenopausal women[J].Eur J Endocrinol, 2005, 153 (2) :327-334.

[2]WEIDERPASS E, PERSSON I, MELHUS H, et al.Estrogen receptor alpha gene polymorphisms and endometrial cancer risk[J].Carcinogenesis, 2000, 21 (4) :623-627.

[3]LI Y, HUANG XZ, ZHANG PA, et al.Study on the relationship between estrogen receptor gene polymorphism and acute myocardial infarction[J].Natl Med J China, 2001, 81 (7) :389-392. (in Chinese) 李艳, 黄宪章, 张平安, 等.雌激素受体基因多态性与急性心肌梗死关系的研究[J].中华医学杂志, 2001, 81 (7) :389-392.

[4]ZHAO YY, ZHOU J, NARAYANAN CS, et al.Estrogen receptor alpha gene polymorphisms and hypertension[J].Hypertens, 1999, 33 (1) :108-115.

[5]GUAN J, WU DH, SHEN H, et al.Relationship between estrogen receptor gene polymorphism and recurrent spontaneous abortion[J].Beijing Med J, 2002, 24 (5) :328-330. (in Chinese) 关菁, 吴丹华, 沈浣, 等.雌激素受体基因多态性与复发性流产的相关性研究[J].北京医学, 2002, 24 (5) :328-330.

[6]XU ZW, ZHAO F, WU HJ.The dual function of ERαcoregulators in the breast cancer[J].Chin J Biochem Mol Biol, 2014, 36 (10) :1437-1442. (in Chinese) 许兆伟, 赵峰, 伍会健.ERα辅调因子在乳腺癌中的双重调控作用[J].中国细胞生物学学报, 2014, 36 (10) :1437-1442.

[7]YAO Y, FENG ST, ZHAO HM, et al.Expression and co-localization of ERαand MTA1 in gastic cancer cells[J].J Jilin Univ:Med Edit, 2013, 39 (1) :5-7. (in Chinese) 姚远, 冯姝婷, 赵鸿梅, 等.雌激素受体alpha和肿瘤转移相关因子1在胃癌细胞中的表达和共定位[J].吉林大学学报:医学版, 2013, 39 (1) :5-7.

[8]XIE JP, GONG XQ, TAN DM, et al.Relationship between estrogen receptor gene polymorphism and hepatitis B cirrhosis[J].J Cent South Univ:Med Sci, 2006, 31 (3) :379-382. (in Chinese) 谢建萍, 龚先琼, 谭德明, 等.雌激素受体基因多态性与乙型肝炎肝硬化的相关性研究[J].中南大学学报:医学版, 2006, 31 (3) :379-382.

[9]DENG G, ZHOU G, ZHAI Y, et al.Assocition of estrogen receptorαpolymorphisms with susceptibility to chronic hepatitis B virus infection[J].Hepatology, 2004, 40 (2) :318-326.

[10] Chinese Society of Hepatology and Chinese society of Infectious Disease, Chinese Medical Association.The guideline of prevention and treatment for chronic hepatitis B (2010 version) [J].Chin J Hepatol, 2011, 19 (1) :13-24. (in Chinese) 中华医学会肝病学分会, 中华医学会感染病学分会.慢性乙型肝炎防治指南 (2010年版) [J].中华肝脏病杂志, 2011, 19 (1) :13-24.

[11]LUO KX, HE C, HE HT, et al.Investigation of hepatitis B virus infection in Han, Tibetan, Dai, Yao, Wei, Meng, and Li populations[J].Chin J Epidemiol, 1993, 14 (5) :266-270. (in Chinese) 骆抗先, 何超, 何海棠, 等.汉藏傣瑶维蒙黎族人群乙型肝炎病毒感染调查[J].中华流行病学杂志, 1993, 14 (5) :266-270.

[12]LONG L, SHAN KR, ZHAO Y, et al.Investigation on association of estrogen receptorαpolymorphism with susceptibility to hepatitis B virus infection in Han nationality and Yao minority from Guizhou province[J].Clin Focus, 2009, 24 (15) :1305-1308. (in Chinese) 龙丽, 单可人, 赵艳, 等.荔波瑶族、汉族雌激素受体α基因多态性与乙型肝炎病毒感染关系的研究[J].临床荟萃, 2009, 24 (15) :1305-1308.

施引文献

资源附件(0)

访问统计