《胰腺癌综合诊治中国专家共识(2014年版)》放射治疗部分的解读

任刚; 王竞; 夏廷毅

doi:10.3969/j.issn.1001-5256.2014.12.005

《胰腺癌综合诊治中国专家共识(2014年版)》放射治疗部分的解读

DOI: 10.3969/j.issn.1001-5256.2014.12.005

1. 空军总医院肿瘤放疗科
2. 解放军总医院放疗科

详细信息

中图分类号: R735.9
计量
- 文章访问数: 127
- HTML全文浏览量: 3
- PDF下载量: 352
- 被引次数: 0
出版历程
- 出版日期: 2014-12-20

Interpretation of radiotherapy document in Chinese expert consensus on comprehensive diagnosis and treatment of pancreatic cancer (2014 Edition)

Department of Radiation Oncology, Chinese PLA Air General Hospital

摘要

摘要:
<正>胰腺癌恶性程度高、预后差,目前没有特别有效的治疗手段,即使早期可接受手术的患者,5年生存率也不及10%。由于胰腺临近大血管、肿瘤发展迅速,初诊时80%的患者无法接受手术根治切除。作为肿瘤治疗三大手段之一的放射治疗,其肿瘤局部控制、止痛疗效显著,已应用到绝大多数胰腺癌患者治疗当中。但胰腺癌毗邻胃肠道组织,传统放疗技术难以提高局部肿瘤照射剂量,几十年来放疗在胰腺癌治疗方面一直停滞
- 胰腺肿瘤 /
- 放射疗法 /
- 中国 /
- 指南 /
- 解读
- pancreatic neoplasms /
- radiotherapy /
- china /
- guidebooks /
- interpretation

HTML全文

参考文献(19)

[1]SPALDING AC, JEE KW, VINEBERG K, et al.Potential for doseescalation and reduction of risk in pancreatic cancer using IMRT optimization with lexicographic ordering and g EUD-based cost functions[J].Med Phys, 2007, 34 (2) :521-529.

[2]MOERTEL CG, FRYTAK S, HAHN RG, et al.Therapy of locally unresectable pancreatic carcinoma:a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000rads+5-fluorouracil) , and high dose radiation+5-fluorouracil:The Gastrointestinal Tumor Study Group[J].Cancer, 1981, 48 (8) :1705-1710.

[3]CHAUFFERT B, MORNEX F, BONNETAIN F, et al.Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer.Definitive results of the 2000-01 FFCD/SFRO study[J].Ann Oncol, 2008, 19 (9) :1592-1599.

[4]LOEHRER PJ SR, FENG Y, CARDENES H, et al.Gemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer:an Eastern Cooperative Oncology Group trial[J].J Clin Oncol, 2011, 29 (31) :4105-4112.

[5]HAMMEL P, HUGUET F, VAN LJ-LEA.Comparison of chemoradiotherapy (CRT) and chemotherapy (CT) in patients with a locally advanced pancreatic cancer (LAPC) controlled after 4 months of gemcitabine with or without erlotinib:final results of the international phase III LAP 07 study[J].J Clin Oncol, 2013, 31 (Suppl) :LBA4003.

[6]SMEENK HG, van EIJCK CH, HOP WC, et al.Long-term survival and metastatic pattern of pancreatic and periampullary cancer after adjuvant chemoradiation or observation:long-term results of EORTC trial 40891[J].Ann Surg, 2007, 246 (5) :734-740.

[7]NEOPTOLEMOS JP, STOCKEN DD, FRIESS H, et al.A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer[J].N Engl J Med, 2004, 350 (12) :1200-1210.

[8]Mc DADE TP, HILL JS, SIMONS JP, et al.A national propensity-adjusted analysis of adjuvant radiotherapy in the treatment of resected pancreatic adenocarcinoma[J].Cancer, 2010, 116 (13) :3257-3266.

[9]STOCKEN DD, BUCHLER MW, DERVENIS C, et al.Meta-analysis of randomised adjuvant therapy trials for pancreatic cancer[J].Br J Cancer, 2005, 92 (8) :1372-1381.

[10]BRESLIN TM, HESS KR, HARBISON DB, et al.Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas:treatment variables and survival duration[J].Ann Surg Oncol, 2001, 8 (2) :123-132.

[11]VARADHACHARY GR, WOLFF RA, CRANE CH, et al.Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head[J].J Clin Oncol, 2008, 26 (21) :3487-3495.

[12]LAURENCE JM, TRAN PD, MORARJI K, et al.A systematic review and meta-analysis of survival and surgical outcomes following neoadjuvant chemoradiotherapy for pancreatic cancer[J].J Gastrointest Surg, 2011, 15 (11) :2059-2069.

[13]WANG J, XIA TY, WANG YJ, et al.Long-term results of gamma ray-based stereotactic body radiotherapy in treatment of medically unfit or inoperable non-metastatic pancreatic adenocarcinoma[J].Int J Radiat Oncol Biol Phys, 2012, 84 (Suppl) :s815-s816.

[14]CHANG DS, LI P, WANG YJ, et al.Clinical outcomes of whole body gamma knife therapy for local pancreatic carcinoma[J].Chin J Radiat Oncol, 2009, 18 (6) :470-473. (in Chinese) 常冬姝, 李平, 王颖杰, 等.全身γ刀治疗局限期胰腺癌临床结果分析[J].中华放射肿瘤学杂志, 2009, 18 (6) :470-473.

[15]LI G, YU YY, HAN C, et al.Efficacy analysis of three-dimensional conformal radiotherapy with increasing dose in late course in pancreatic cancer pantients[J].J Chin Med Univ, 2012, 41 (12) :1134-1143. (in Chinese) 李光, 于洋洋, 韩冲, 等.81例胰腺癌后程加量三维适形放疗的疗效分析[J].中国医科大学学报, 2012, 41 (12) :1134-1143.

[16]NAKAMURA A, SHIBUYA K, MATSUO Y, et al.Analysis of dosimetric parameters associated with acute gastrointestinal toxicity and upper gastrointestinal bleeding in locally advanced pancreatic cancer patients treated with gemcitabine-based concurrent chemoradiotherapy[J].Int J Radiat Oncol Biol Phys, 2012, 84 (2) :369-375.

[17]YOVINO S, POPPE M, JABBOUR S, et al.Intensity-modulated radiation therapy significantly improves acute gastrointestinal toxicity in pancreatic and ampullary cancers[J].Int J Radiat Oncol Biol Phys, 2011, 79 (1) :158-162.

[18]CHANG DT, SCHELLENBERG D, SHEN J, et al.Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas[J].Cancer, 2009, 115 (3) :665-672.

[19]XIA TY, CHANG DS, WANG YJ, et al.Dose escalation to target volumes of helical tomotherapy for pancreatic cancer in the phase I-II clinical trial[J].Int J Radiat Oncol Biol Phys, 2013, 87 (Suppl) :s303.

施引文献

资源附件(0)

访问统计