慢加急性肝衰竭预后标志物的研究进展

张玉玲; 韩涛; 张敏; 张倩

doi:10.3969/j.issn.1001-5256.2014.10.026

慢加急性肝衰竭预后标志物的研究进展

DOI: 10.3969/j.issn.1001-5256.2014.10.026

天津医科大学三中心临床学院,天津市第三中心医院肝内科,天津市人工细胞重点实验室,天津市肝胆疾病研究所

基金项目:

艾滋病和病毒性肝炎等重大传染病防治国家科技重大专项(2012ZX10002004-011)；天津市科技计划项目(13RCGFSY19200)；

详细信息

中图分类号: R575.3
计量
- 文章访问数: 2564
- HTML全文浏览量: 11
- PDF下载量: 1300
- 被引次数: 0
出版历程
- 收稿日期: 2014-03-25
- 出版日期: 2014-10-20

Research progress in prognostic markers of acute-on-chronic liver failure

The Third Central Clinical College of Tianjin Medical University

Research funding:

摘要

摘要: 慢加急性肝衰竭表现为肝功能急性恶化且伴随一个或多个器官衰竭的临床症候群,其短期病死率高。近年来,一些反映慢加急性肝衰竭预后的新标志物不断涌现,为慢加急性肝衰竭的治疗及预后评估提供依据。简述了反映慢加急性肝衰竭预后的临床常用的以及新型标志物的相关研究,旨在完善现有的预后评估系统,为慢加急性肝衰竭的治疗及预后评估提供依据。
- 肝功能衰竭 /
- 预后 /
- 综述
Abstract: Acute-on-chronic liver failure ( ACLF) is a clinical entity encompassing an acute deterioration of liver function and failure of one or more organs, which results in high short-term mortality rate. In recent years, a number of novel prognostic markers of ACLF have emerged and provided a basis for the treatment and prognostic evaluation of ACLF. Researches on both commonly used and novel makers for prognosis of ACLF are reviewed in order to improve the existing prognostic evaluation system and to provide a basis for the treatment and prognostic evaluation of ACLF.
- liver failure /
- prognosis /
- review

HTML全文

参考文献(36)

[1]SARIN SK, KUMAR A, ALMEIDA JA, et al.Acute-on-chronic liver failure:consensus recommendations of the Asian Pacific Association for the study of the liver (APASL) [J].Hepatol Int, 2009, 3 (1) :269-282.

[2]LIU M, ZHANG XQ, MAO Q.Features of acute-on-chronic preliver failure and establishment of a predictive model for risk of acuteon-chronic liver failure[J].J Clin Hepatol, 2012, 28 (10) :732-734. (in Chinese) 刘明, 张绪清, 毛青.慢加急性肝衰竭前期的概念及预警模型[J].临床肝胆病杂志, 2012, 28 (10) :732-734.

[3]HE WP, HU JH, ZHAO J, et al.Comparison of four prognostic models and a new Logistic regression model to predict short-term prognosis of acute-on-chronic hepatitis B liver failure[J].Chin Med J (Engl) , 2012, 125 (13) :2272-2278.

[4]XIA Q, DAI X, ZHANG Y, et al.A modified MELD model for Chinese pre-ACLF and ACLF patients and it reveals poor prognosis in pre-ACLF patients[J].PLoS One, 2013, 8 (6) :e64379.

[5]ZHENG MH, SHI KQ, LIN XF, et al.A model to predict 3-month mortality risk of acute-on-chronic hepatitis B liver failure using artificial neural network[J].J Viral Hepat, 2013, 20 (4) :248-255.

[6]DUSEJA A, CHOUDHARY NS, GUPTA S, et al.APACHE II score is superior to SOFA, CTP and MELD in predicting the short-term mortality in patients with acute-on-chronic liver failure (ACLF) [J].J Dig Dis, 2013, 14 (9) :484-490.

[7]CHOLONGITAS E, THEOCHARIDOU E, VASIANOPOULOU P, et al.Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure[J].Liver Transpl, 2012, 18 (4) :405-412.

[8]MOREAU R, JALAN R, GINES P, et al.Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis[J].Gastroenterology, 2013, 144 (7) :1426-1437.

[9]THEOCHARIDOU E, PIERI G, MOHAMMAD AO, et al.The Royal Free Hospital Score:a calibrated prognostic model for patients with cirrhosis admitted to intensive care unit.Comparison with current models and CLIF-SOFA Score[J].Am J Gastroenterol, 2014, 109 (4) :554-562.

[10]PAN XF, ZHANG K, YANG XA, et al.Interleukin-21 expression in serum of patients with acute-on-chronic liver failure and its significance[J].Chin J Exp Clin Virol, 2012, 26 (6) :477-479. (in Chinese) 潘兴飞, 张卡, 杨小安, 等.慢加急性肝衰竭患者外周血IL-21水平检测及其意义[J].中华实验和临床病毒学杂志, 2012, 26 (6) :477-479.

[11]WANG LY, FAN YC, ZHAO J, et al.Elevated expression of tumour necrosis factor-alpha-induced protein 8 (TNFAIP8) -like 2 mRNA in peripheral blood mononuclear cells is associated with disease progression of acute-on-chronic hepatitis B liver failure[J].J Viral Hepat, 2014, 21 (1) :64-73.

[12]YE H, WANG LY, ZHAO J, et al.Increased CD163 expression is associated with acute-on-chronic hepatitis B liver failure[J].World J Gastroenterol, 2013, 19 (18) :2818-2825.

[13]WANG P, XU B, ZHANG LJ.Changes and clinical significances of Treg and Th17 cells in the peripheral blood of patients with different types of hepatitis B virus infection[J].Chin J Immunol, 2013, 29 (6) :618-624. (in Chinese) 王萍, 胥冰, 张丽君.不同类型HBV感染者外周血Treg/Th17细胞的变化及意义[J].中国免疫学杂志, 2013, 29 (6) :618-624.

[14]ZHANG GL, XIE DY, LIN BL, et al.Imbalance of interleukin-17-producing CD4 T cells/regulatory T cells axis occurs in remission stage of patients with hepatitis B virus-related acute-on-chronic liver failure[J].J Gastroenterol Hepatol, 2013, 28 (3) :513-521.

[15]NIU YH, YIN DL, LIU HL, et al.Restoring the Treg cell to Th17cell ratio may alleviate HBV-related acute-on-chronic liver failure[J].World J Gastroenterol, 2013, 19 (26) :4146-4154.

[16]SHI F, ZHANG JY, ZENG Z, et al.Skewed ratios between CD3+T cells and monocytes are associated with poor prognosis in patients with HBV-related acute-on-chronic liver failure[J].Biochem Biophys Res Commun, 2010, 402 (1) :30-36.

[17] LIU XY, SHI F, ZHAO H, et al.Research of PD-1 expression in CD8+T cell of Peripheral blood with HBV-associated acute-onchronic liver failure[J].Chin J Exp Clin Virol, 2010, 24 (2) :125-127. (in Chinese) 刘晓燕, 石峰, 赵鸿, 等.PD-1受体在HBV-ACLF患者外周血CD8+T细胞上的表达研究[J].中华实验和临床病毒学杂志, 2010, 24 (2) :125-127.

[18]CAO D, XU H, GUO G, et al.Intrahepatic expression of programmed death-1 and its ligands in patients with HBV-related acute-onchronic liver failure[J].Inflammation, 2013, 36 (1) :110-120.

[19]SHI WJ, WEI L, TIAN PF, et al.Serum levels of Th1/Th2 cytokines in HBV-related acute-on-chronic liver failure patients[J].Chin Hepatol, 2013, 18 (1) :27-29. (in Chinese) 施文娟, 魏丽, 田鹏飞, 等.HBV相关慢加急性肝衰竭患者血清Th1/Th2型细胞因子水平的研究[J].肝脏, 2013, 18 (1) :27-29.

[20]CHEN R, HOU W, ZHANG Q, et al.Emerging role of highmobility group box 1 (HMGB1) in liver diseases[J].Mol Med, 2013, 19 (11) :357-366.

[21]DUAN XZ, HU JH, LI C, et al.Relation between serum levels of high mobility group box 1 and hepatitis B virus-related acute-on-chronic liver failure[J].Chin J Hepatol, 2013, 21 (6) :434-437. (in Chinese) 段学章, 胡瑾华, 李晨, 等.血清高迁移率族蛋白1在乙型肝炎病毒相关慢加急性肝衰竭患者中的特点及其临床意义[J].中华肝脏病杂志, 2013, 21 (6) :434-437.

[22]LI X, WANG LK, WANG LW, et al.Blockade of high-mobility group box-1 ameliorates acute on chronic liver failure in rats[J].Inflamm Res, 2013, 62 (7) :703-709.

[23]OETTL K, BIRNER-GRUENBERGER R, SPINDELBOECK W, et al.Oxidative albumin damage in chronic liver failure:relation to albumin binding capacity, liver dysfunction and survival[J].J Hepatol, 2013, 59 (5) :978-983.

[24]LIU H, HAN T, TIAN J, et al.Monitoring oxidative stress in acute-on-chronic liver failure by advanced oxidation protein products[J].Hepatol Res, 2012, 42 (2) :171-180.

[25]ELFIMOVA N, SCHLATTJAN M, SOWA JP, et al.Circulating microRNAs:promising candidates serving as novel biomarkers of acute hepatitis[J].Front Physiol, 2012, 3 (12) :476.

[26]YU DS, AN FM, GONG BD, et al.The regulatory role of microRNA-1187 in TNF-alpha-mediated hepatocyte apoptosis in acute liver failure[J].Int J Mol Med, 2012, 29 (4) :663-668.

[27]NG R, SONG G, ROLL GR, et al.A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration[J].J Clin Invest, 2012, 122 (3) :1097-1108.

[28]YUAN Q, LOYA K, RANI B, et al.MicroRNA-221 overexpression accelerates hepatocyte proliferation during liver regeneration[J].Hepatology, 2013, 57 (1) :299-310.

[29]YU ZY, BAI YN, LUO LX, et al.Expression of microRNA-150targeting vascular endothelial growth factor-A is downregulated under hypoxia during liver regeneration[J].Mol Med Rep, 2013, 8 (1) :287-293.

[30]DAI XH, ZHANG P, XIAO MF, et al.Protective role ofα2HS-glycoprotein in HBV-associated liver failure[J].Int J Mol Sci, 2011, 12 (6) :3846-3856.

[31]PENG L, LIU J, LI YM, et al.Serum proteomics analysis and comparisons using iTRAQ in the progression of hepatitis B[J].Exp Ther Med, 2013, 6 (5) :1169-1176.

[32]HAN T, LIU Y, LIU H, et al.Serum thymosin beta4 levels in patients with hepatitis B virus-related liver failure[J].World J Gastroenterol, 2010, 16 (5) :625-630.

[33]REN F, CHEN Y, WANG Y, et al.Comparative serum proteomic analysis of patients with acute-on-chronic liver failure:alpha-1-acid glycoprotein maybe a candidate marker for prognosis of hepatitis B virus infection[J].J Viral Hepat, 2010, 17 (11) :816-824.

[34]WEN T, GOU CY, LU J, et al.Changes of extracellular histones in mice with acute liver failure and its therapeutic potential[J].Chin J Emerg Med, 2013, 22 (2) :148-152. (in Chinese) 温韬, 勾春燕, 卢静, 等.细胞外组蛋白在急性肝衰竭小鼠中的变化[J].中华急诊医学杂志, 2013, 22 (2) :148-152.

[35]MAO Y, HUANG X, YU K, et al.Metabonomic analysis of hepatitis B virus-induced liver failure:identification of potential diagnostic biomarkers by fuzzy support vector machine[J].J Zhejiang Univ Sci B, 2008, 9 (6) :474-481.

[36]NIE CY, HAN T, ZHANG L, et al.Cross-sectional and dynamic change of serum metabolite profiling for Hepatitis B-related acute-on-chronic liver failure by UPLC/MS[J].J Viral Hepat, 2014, 21 (1) :53-63.

施引文献

资源附件(0)

访问统计