细胞因子风暴与肝衰竭

陈智; 朱海红; 杨英

doi:10.3969/j.issn.1001-5256.2014.10.003

细胞因子风暴与肝衰竭

DOI: 10.3969/j.issn.1001-5256.2014.10.003

浙江大学医学院附属第一医院传染病诊治国家重点实验室

基金项目:

国家科技部“十二五”重大专项(2012ZX10002)；

详细信息

中图分类号: R575.3
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出版历程
- 收稿日期: 2014-09-07
- 出版日期: 2014-10-20

Cytokine storm and liver failure

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University

Research funding:

摘要

摘要: 细胞因子风暴(cytokine storm)在肝衰竭发病机制中起十分重要的作用,与肝衰竭过程中的肝细胞坏死和疾病临床预后密切相关。介绍了以Kupffer细胞为线索,肝衰竭发生、发展过程中各相关细胞及细胞因子相互影响、共同作用,导致肝组织严重损伤和坏死的机制。指出细胞因子的研究,将有助于肝衰竭早期诊断、病情分析和个体化治疗水平的提高。
- 肝功能衰竭 /
- 细胞因子 /
- 枯否细胞
Abstract: Cytokine storm plays an important role in the pathogenesis of liver failure. It is closely related to hepatocyte necrosis in the clinical course and the prognosis of this disease. With Kupffer cells as a clue, it is elucidated that related cells and cytokines influence each other and jointly function in the development and progression of liver failure, leading to serious liver tissue damage and necrosis. Cytokine-based research can help improve early diagnosis, disease assessment, and individualized treatment for liver failure.
- liver failure /
- cytokine /
- kupffer cells

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参考文献(7)

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