循环miRNA在肝胆疾病诊断中的研究进展

彭小芳; 刘海英

doi:10.3969/j.issn.1001-5256.2014.09.032

循环miRNA在肝胆疾病诊断中的研究进展

DOI: 10.3969/j.issn.1001-5256.2014.09.032

广州医科大学附属广州市妇女儿童医疗中心临床检验部

基金项目:

广州市卫生局西医类重点项目(201102A212023)；国家自然科学基金资助项目(81172839)；广州市卫生局医药科技一般引导项目(2013A010012)；

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2013-11-08
- 出版日期: 2014-09-20

Research advances in circulating miRNAs for diagnosis of hepatobiliary diseases

Clinical Laboratory, Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University

Research funding:

摘要

摘要: 微小核糖核酸(microRNA),简称miRNA,参与着生命活动的病理生理过程,在人体血清、血浆等体液中存在丰富而稳定的循环miRNA。简述了循环miRNA与病毒性肝炎、肝纤维化、肝硬化、肝癌、药物性肝炎等肝胆疾病或疾病不同阶段的表达谱存在明显差异性,其中一些循环miRNA可作为相关疾病早期诊断、病情进展和预后评估的新型无创性生物标志。本文就循环miRNA在肝胆疾病诊断研究中的最新进展作一综述。
- 肝疾病 /
- 胆道疾病 /
- 微RNAs /
- 诊断 /
- 综述
Abstract: MicroRNAs ( miRNAs) are involved in the pathological and physiological process of life activities, and some of them exist stably and abundantly in serum, plasma, and other body fluids. Previous studies have indicated that there are significant differences in the expression patterns of circulating miRNAs between patients with viral hepatitis, liver fibrosis, liver cirrhosis, hepatocellular carcinoma, drug- induced hepatitis, and other hepatobiliary diseases at different disease stages. Among these circulating miRNAs, some can act as novel noninvasive biomarkers for the early diagnosis, disease progression, and prognostic evaluation of related diseases. The latest research advances in circulating miRNAs for the diagnosis of hepatobiliary diseases are reviewed.
- liver diseases /
- biliary tract diseases /
- microRNAs /
- diagnosis /
- review

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参考文献(28)

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