肝脏固有免疫系统研究现状

叶传涛; 魏欣; 张颖

doi:10.3969/j.issn.1001-5256.2014.09.003

肝脏固有免疫系统研究现状

DOI: 10.3969/j.issn.1001-5256.2014.09.003

第四军医大学唐都医院感染病·肝病中心

基金项目:

国家科技部十二五重大专项基金资助项目(2013ZX10004609)；国家自然科学基金资助项目(31170877,81170389,81273218)；

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2014-06-18
- 出版日期: 2014-09-20

Current status of research on liver innate immunity

Center of Infectious Diseases and Liver Diseases, Tangdu Hospital, Fourth Military Medical University

Research funding:

摘要

摘要: 肝脏固有免疫系统在抵御外来病原体入侵过程中发挥重要作用。叙述了肝脏固有免疫系统抵御病原体入侵的机制,包括肝脏特殊的解剖及生理特征,肝脏固有免疫细胞(肝脏定居细胞和血循环募集细胞)特性及其在病原体入侵过程中发挥功能的机制与相互联系,肝脏固有免疫细胞对病原体的识别及效应机制,肝脏免疫损伤及免疫耐受形成的机制。认为对于肝脏固有免疫细胞及固有免疫分子的研究还需更加深入,进一步了解肝脏作为独立的免疫系统与机体整体的免疫系统之间的联系与区别,将会对肝脏疾病的诊治及更深层次研究有极大的促进作用。
- 肝疾病 /
- 免疫,天然 /
- 免疫耐受 /
- 超敏反应
Abstract: Liver innate immunity plays an important role in the defense against pathogen invasion. The mechanisms of liver innate immunity for defending against pathogen invasion are reviewed, including the special anatomical and physiological characteristics of the liver, the features of innate immune cells in the liver ( liver- settled cells and cells raised from blood circulation) and their function and relationship with each other in pathogen invasion, the process of pathogen identification and effect of liver innate immune cells, and the mechanism of liver immune injury and immune tolerance. Given current research on innate immune cells and innate immune molecules in the liver, further studies should be conducted to understand the connection and difference between liver innate immunity and systemic immunity, thus promoting the diagnosis and treatment of liver diseases and deeper research.
- liver diseases /
- immunity, natural /
- immune tolerance /
- hypersensitivity

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参考文献(31)

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