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提高肝脏免疫功能认知,加强肝病细胞治疗研究

贾战生 连建奇

引用本文:
Citation:

提高肝脏免疫功能认知,加强肝病细胞治疗研究

DOI: 10.3969/j.issn.1001-5256.2014.09.001
基金项目: 

国家科技部十二五重大专项基金资助项目(2013ZX10004609); 国家自然科学基金资助项目(31170877,81170389,81273218); 

详细信息
  • 中图分类号: R575

Improving understanding of liver immune function and enhancing research on cell therapy for liver diseases

Research funding: 

 

  • 摘要: 肝脏是一个重要的免疫器官,具有独特的免疫微环境,参与全身固有免疫应答和适应性免疫反应。肝脏通过肝-肠轴与系统免疫密切相连,又是免疫损伤的靶器官;肝脏在抗嗜肝病毒免疫中发挥着重要作用,但导致病毒感染慢性化机制尚不完全清楚。肝病细胞治疗包括以细胞功能替代为主的肝(干)细胞输入治疗;以抗病毒抗肿瘤为主的免疫细胞治疗和对遗传性肝病进行的以细胞为载体的基因治疗。间充质干细胞的多向分化潜能和免疫调节特性成为肝病细胞治疗的热点,体外高效扩增技术使自然杀伤细胞治疗肝癌成为可能。

     

  • [1]RACANELLI V, REHERMANN B.The liver as an immunological organ[J].Hepatology, 2006, 43 (2 Suppl 1) :s54-s62.
    [2]PATMAN G.Liver transplantation:Immune responses to HCV infection linked to liver transplant tolerance[J].Nat Rev Gastroenterol Hepatol, 2014, 11 (8) :454.
    [3]JENNE CN, KUBES P.Immune surveillance by the liver[J].Nat Immunol, 2013, 14 (10) :996-1006.
    [4]KNOLLE PA, LIMMER A.Control of immune responses by savenger liver endothelial cells[J].Swiss Med Wkly, 2003, 133 (37-38) :501-506.
    [5]KACZMAREK J, HOMSI Y, vanM J, et al.Liver sinusoidal endothelial cell-mediated CD8 T cell priming depends on co-inhibitory signal integration over time[J].PLoS One, 2014, 9 (6) :e99574.
    [6]YOU Q, CHENG L, KEDL RM, et al.Mechanism of T cell tolerance induction by murine hepatic Kupffer cells[J].Hepatology, 2008, 48 (3) :978-990.
    [7]NAKAMOTO N, KANAI T.Role of toll-like receptors in immune activation and tolerance in the liver[J].Front Immunol, 2014, 5:221.
    [8] HUTCHINS NA, WANG F, WANG Y, et al.Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1[J].J Leukoc Biol, 2013, 94 (5) :963-970.
    [9]SWAIN MG.Natural killer T cells within the liver:conductors of the hepatic immune orchestra[J].Dig Dis, 2010, 28 (1) :7-13.
    [10] SON G, KREMER M, HINES IN.Contribution of gut bacteria to liver pathobiology[J].Gastroenterol Res Pract, 2010, 2010.doi: 10.1155/2010/453563.
    [11]SANA G, LOMBARD C, VOSTERS O, et al.Adult human hepatocytes promote CD4+T cell hyporesponsiveness via interleukin-10 producing allogeneic dendritic cells[J].Cell Transplant, 2013.[Epub ahead of print]
    [12]SZABO G, BALA S, PETRASEK J, et al.Gut-liver axis and sensing microbes[J].Dig Dis, 2010, 28 (6) :737-744.
    [13] WLODARSKA M, THAISS CA, NOWARSKI R, et al.NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion[J].Cell, 2014, 156 (5) :1045-1059.
    [14] GALICIA-CARREN J, SANTACRUZ C, AYALA-BALBOA J, et al.An imbalance between frequency of CD4+CD25+FOXP3+regulatory T cells and CCR4+and CCR9+circulating helper T cells is associated with active perennial allergic conjunctivitis[J].Clin Dev Immunol, 2013, 2013:919742.
    [15]LIANG XS, LI CZ, ZHOU Y, et al.Changes in circulating Foxp3 (+) regulatory T cells and interleukin-17-producing T helper cells during HBV-related acute-on-chronic liver failure[J].World J Gastroenterol, 2014, 20 (26) :8558-8571.
    [16]SAHA B, SZABO G.Innate immune cell networking in hepatitis C virus infection[J].J Leukoc Biol, 2014.[Epub ahead of print]
    [17]ZHOU Y, ZHANG Y, MOORMAN JP, et al.Viral (HCV, HBV, HIV) persistence and immune homeostasis[J].Immunology, 2014.[Epub ahead of print]
    [18]DUSTIN LB, CASHMAN SB, LAIDLAW SM.Immune control and failure in HCV infection-tipping the balance[J].J Leukoc Biol, 2014.[Epub ahead of print]
    [19]DADAGLIO G, FAYOLLE C, ZHANG X, et al.Antigen targeting to CD11b+dendritic cells in association with TLR4/Toll/IL-1R domain-containing adapter-inducing IFN-beta signaling promotes strong CD8+T cell responses[J].J Immunol, 2014, 193 (4) :1787-1798.
    [20]CRISPE IN, PIERCE RH.Killer T cells find meaningful encounters through iMATEs[J].Nat Immunol, 2013, 14 (6) :533-534.
    [21]JIA ZS.Cell therapy for liver diseases:basic and clinical[M].Beijing:Peole's Medical Publishing House, 2005:246-259. (in Chinese) 贾战生.肝病细胞治疗:基础与临床[M].北京:人民卫生出版社, 2005:246-259.
    [22]XIAO JQ, SHI XL, MA HC, et al.Administration of IL-1Ra chitosan nanoparticles enhances the therapeutic efficacy of mesenchymal stem cell transplantation in acute liver failure[J].Arch Med Res, 2013, 44 (5) :370-379.
    [23] QIN S, JIANG H, SU S, et al.Inhibition of hepatic stellate cell proliferation by bone marrow mesenchymal stem cells via regulation of the cell cycle in rat[J].Exp Ther Med, 2012, 4 (3) :375-380.
    [24] CHEN JF, WANG KW, ZHANG SQ, et al.Dexamethasone in outcome of patients with hepatitis B virus-related acute-on-chronic liver failure[J].J Gastroenterol Hepatol, 2014, 29 (4) :800-806.
    [25]SUI Q, ZHANG J, SUN X, et al.NK cells are the crucial antitumor mediators when STAT3-Mediated immunosuppression is blocked in hepatocellular carcinoma[J].J Immunol, 2014, 193 (4) :2016-2023.引证本文:JIA ZS, LIAN JQ.Improving understanding of liver immune function and enhancing research on cell therapy for liver diseases[J].J Clin Hepatol, 2014, 30 (9) :839-841. (in Chinese) 贾战生, 连建奇.提高肝脏免疫功能认知, 加强肝病细胞治疗研究[J].临床肝胆病杂志, 2014, 30 (9) :839-841.
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  • 收稿日期:  2014-07-30
  • 出版日期:  2014-09-20
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