代谢组学在肝细胞癌标志物研究中的应用

王建钢; 李华成; 费新应

doi:10.3969/j.issn.1001-5256.2014.08.039

代谢组学在肝细胞癌标志物研究中的应用

DOI: 10.3969/j.issn.1001-5256.2014.08.039

1. 湖北中医药大学
2. 黄石中医医院(传染病医院)

基金项目:

湖北省自然科学基金项目(2011CDB170)；

详细信息

中图分类号: R735.7
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出版历程
- 收稿日期: 2013-08-20
- 出版日期: 2014-08-20

Application of metabolomics in research on biomarkers for hepatocellular carcinoma

Hubei University of Chinese Medicine

Research funding:

摘要

摘要: 代谢组学技术作为一种新的组学研究手段,能够揭示肝细胞癌(HCC)发生发展过程中的代谢谱差异,成为HCC生物标志物研究的热点。简述了代谢组学在HCC诊断中的意义,概括了HCC相关的生物标志物的代谢组学研究,这些研究主要以血清、尿液及肝组织代谢物为对象,通过动物实验和临床研究两个方面进行。指出分析和监视HCC发生发展过程中相应代谢物的变化,对于患者的个体化治疗具有重要价值。
- 癌,肝细胞 /
- 肿瘤标记,生物学 /
- 甲胎蛋白类
Abstract: As a novel research tool, metabolomics technology can reveal the differences in metabolic profiles during the development and progression of hepatocellular carcinoma (HCC) , so it has been widely applied for research on HCC biomarkers.The significance of metabolomics in the diagnosis of HCC is briefly described, and the metabolomics research aiming at the discovery of HCC biomarkers, including animal experiments and clinical studies of metabolites in the serum, urine, and liver tissue, is reviewed.It is pointed out that analyzing and monitoring metabolites in the development and progression of HCC is of great significance for individualized treatment.
- carcinoma, hepatocellular /
- tumor markers, biological /
- alpha-fetoproteins

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参考文献(28)

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