外周血单核细胞中HBV cccDNA检测的意义及进展

蔡少平; 刘泽; 徐东平

doi:10.3969/j.issn.1001-5256.2014.08.034

外周血单核细胞中HBV cccDNA检测的意义及进展

DOI: 10.3969/j.issn.1001-5256.2014.08.034

1. 解放军医学院
2. 解放军302医院军人肝病诊疗中心

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中图分类号: R512.62
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出版历程
- 收稿日期: 2013-08-27
- 出版日期: 2014-08-20

Significance and progress in detection of HBV cccDNA in peripheral blood mononuclear cells

Chinese , PLA Medical School

摘要

摘要: HBV在复制过程中存在着共价闭合环状DNA(cccDNA)形式,cccDNA是HBV复制的原始模板,是HBV持续感染的主要原因,也是HBV一个重要生物活性指标。HBV是嗜肝病毒,但可能存在肝外感染,有研究表明,外周血单核细胞(PBMC)中可以检测到HBV cccDNA。归纳了PBMC中HBV cccDNA在乙型肝炎患者肝移植术后及抗病毒治疗后HBV复发、HBV母婴传播中的预测作用,以及其参与HBV肝外感染的可能机制。由此可见,PBMC HBV cccDNA在HBV的治疗及研究中有重要意义。
- 肝炎病毒,乙型 /
- DNA,环状 /
- 单核细胞
Abstract: Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is an intermediate replicative episome which is stable and not easy to eliminate.cccDNA serves as the template for HBV replication and plays an important role in persistence of HBV infection in hepatocytes, and it is also a biomarker of HBV activity.Studies suggested that HBV has extrahepatic infectivity and cccDNA could be detected in peripheral blood mononuclear cells (PBMC) .The predictive values of HBV cccDNA in PBMC for HBV recurrence after liver transplantation and antiviral therapy and mother- to- child transmission of HBV in patients with hepatitis B, as well as the possible mechanism of cccDNA involved in extrahepatic HBV infection, are summarized.Therefore, the detection of HBV cccDNA is of great significance for the study and treatment of HBV.
- hepatitis B virus /
- DNA, circular /
- monocytes

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