胰腺癌与糖尿病关系的研究进展

何相宜; 袁耀宗

doi:10.3969/j.issn.1001-5256.2014.08.009

胰腺癌与糖尿病关系的研究进展

DOI: 10.3969/j.issn.1001-5256.2014.08.009

上海交通大学医学院附属瑞金医院消化科

详细信息

中图分类号: R735.9
计量
- 文章访问数: 2828
- HTML全文浏览量: 12
- PDF下载量: 603
- 被引次数: 0
出版历程
- 收稿日期: 2014-05-13
- 出版日期: 2014-08-20

Research advances in relationship between diabetes and pancreatic cancer

Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

摘要

摘要: 胰腺癌是消化系统常见的恶性肿瘤之一,恶性程度高,诊断时往往已是晚期,预后极差。数年来流行病学研究显示糖尿病与胰腺癌关系密切,近年来的多项临床回顾性研究以及分子机制研究对糖尿病与胰腺癌的关系有了新的认识,尤其是新发糖尿病与胰腺癌的关系,抗糖尿病药物对胰腺癌的作用,胰腺癌与糖尿病相互关联的分子基础等。目前认为长期糖尿病是胰腺癌发生的危险因素之一,新发糖尿病可能帮助早期诊断胰腺癌,糖尿病本身可能影响胰腺癌的预后,而抗糖尿病药物的不同选择亦可能影响胰腺癌发生概率,对糖尿病促进胰腺癌分子机制的研究则有助于寻找胰腺癌治疗的新靶点。
- 胰腺肿瘤 /
- 糖尿病 /
- 早期诊断 /
- 危险因素 /
- 综述
Abstract: Pancreatic cancer (PC) is one of common malignant digestive diseases.It is mostly diagnosed at advanced stage, with an extremely poor progression.The relationship between diabetes and PC was shown by numerous epidemiological studies for decades.Retrospective clinical studies and research on molecular mechanisms in recent years have led to a new understanding of the relationship between diabetes, especially new- onset diabetes, and PC, the effect of antidiabetic medication on PC, and the molecular mechanisms underlying the connection between diabetes and PC.It is suggested by recent data that long- standing diabetes is one of the risk factors for PC development, new- onset diabetes may facilitate early diagnosis of PC, diabetes may have an impact on the prognosis of PC, the option of antidiabetic medication may influence the incidence of PC, and exploring the molecular mechanisms underlying the association between diabetes and PC may help to identify the new therapeutic target for PC.
- pancreatic neoplasms /
- diabetes mellitus /
- early diagnosis /
- risk factors /
- review

HTML全文

参考文献(29)

[1]MUNIRAJ T, CHARI ST.Diabetes and pancreatic cancer[J].Minerva Gastroenterol Edietologica, 2012, 58 (4) :331-345.

[2]PANNALA R, LEIRNESS JB, BAMLET WR, et al.Prevalence and clinical profile of pancreatic cancer-associated diabetes mellitus[J].Gastroenterology, 2008, 134 (4) :981-987.

[3]AGGARWAL G, KAMADA P, CHARI ST.Prevalence of diabetes mellitus in pancreatic cancer compared to common cancers[J].Pancreas, 2013, 42 (2) :198-201.

[4]CHAUDHRY ZW, HALL E, KALYANI RR, et al.Diabetes and pancreatic cancer[J].Curr Prob Cancer, 2013, 37 (5) :287-292.

[5]LI D, TANG H, HASSAN MM, et al.Diabetes and risk of pancreatic cancer:a pooled analysis of three large case-control studies[J].Cancer Causes Control, 2011, 22 (2) :189-197.

[6]BEN Q, XU M, NING X, et al.Diabetes mellitus and risk of pancreatic cancer:a meta-analysis of cohort studies[J].Eur J Cancer, 2011, 47 (13) :1928-1937.

[7]LEE MS, HSU CC, WAHLQVIST ML, et al.Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese:a representative population prospective cohort study of 800, 000 individuals[J].BMC Cancer, 2011, 11:20.

[8]ELENA JW, STEPLOWSKI E, YU K, et al.Diabetes and risk of pancreatic cancer:a pooled analysis from the pancreatic cancer cohort consortium[J].Cancer Causes Control, 2013, 24 (1) :13-25.

[9]HE XY, LI JF, YAO WY, et al.Resolution of new-onset diabetes after radical pancreatic resection predicts long-term survival in patients with pancreatic ductal cell adenocarcinoma[J].Ann Surg Oncol, 2013, 20 (12) :3809-3816.

[10]KUANG TT, JIN DA Y, WANG DS, et al.Clinical epidemiological analysis of the relationship between pancreatic cancer and diabetes mellitus:data from a single institution in China[J].J Dig Dis, 2009, 10 (1) :26-29.

[11]MIZUNO S, NAKAI Y, ISAYAMA H, et al.Diabetes is a useful diagnostic clue to improve the prognosis of pancreatic cancer[J].Pancreatology, 2013, 13 (3) :285-289.

[12]PANNALA R, BASU A, PETERSEN GM, et al.New-onset diabetes:a potential clue to the early diagnosis of pancreatic cancer[J].Lancet Oncol, 2009, 10 (1) :88-95.

[13]MIZUNO S, NAKAI Y, ISAYAMA H, et al.Risk factors and early signs of pancreatic cancer in diabetes:screening strategy based on diabetes onset age[J].J Gastroenterol, 2013, 48 (2) :238-246.

[14]WU JM, KUO TC, YANG CY, et al.Resolution of diabetes after pancreaticoduodenectomy in patients with and without pancreatic ductal cell adenocarcinoma[J].Ann Surg Oncol, 2012, 20 (1) :242-249.

[15]CANNON RM, LeGRAND R, CHAGPAR RB, et al.Multi-institutional analysis of pancreatic adenocarcinoma demonstrating the effect of diabetes status on survival after resection[J].HPB (Oxford) , 2012, 14 (4) :228-235.

[16]RAGHAVAN SR, BALLEHANINNA UK, CHAMBERLAIN RS.The impact of perioperative blood glucose levels on pancreatic cancer prognosis and surgical outcomes:an evidence-based review[J].Pancreas, 2013, 42 (8) :1210-1217.

[17]CHEON YK, KOO JK, LEE YS, et al.Elevated hemoglobin A1c levels are associated with worse survival in advanced pancreatic cancer patients with diabetes[J].Gut Liver, 2014, 8 (2) :205-214.

[18]TORIOLA AT, STOLZENBERG-SOLOMON R, DALIDOWITZ L, et al.Diabetes and pancreatic cancer survival:a prospective cohort-based study[J].Br J Cancer, 2014.[Epub ahead of print]

[19]YACHIDA S, JONES S, BOZIC I, et al.Distant metastasis occurs late during the genetic evolution of pancreatic cancer[J].Nature, 2010, 467 (7319) :1114-1117.

[20]CHIU CC, HUANG CC, CHEN YC, et al.Increased risk of gastrointestinal malignancy in patients with diabetes mellitus and correlations with anti-diabetes drugs:a nationwide population-based study in Taiwan[J].Intern Med, 2013, 52 (9) :939-946.

[21]WANG Z, LAI ST, XIE L, et al.Metformin is associated with reduced risk of pancreatic cancer in patients with type 2 diabetes mellitus:a systematic review and meta-analysis[J].Diabetes Res Clin Pract, 2014.[Epub ahead of print].

[22]TANG H, WEI P, DUELL EJ, et al.Genes-environment interactions in obesity-and diabetes-associated pancreatic cancer:a GWAS data analysis[J].Cancer Epidemiol Biomarkers Prev, 2014, 23 (1) :98-106.

[23]KISFALVI K, EIBL G, SINNETT-SMITH J, et al.Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth[J].Cancer Res, 2009, 69 (16) :6539-6545.

[24]LI W, YUAN Y, HUANG L, et al.Metformin alters the expression profiles of microRNAs in human pancreatic cancer cells[J].Diabetes Res Clin Pract, 2012, 96 (2) :187-195.

[25]LI D, YEUNG SC, HASSAN MM, et al.Antidiabetic therapies affect risk of pancreatic cancer[J].Gastroenterology, 2009, 137 (2) :482-488.

[26]SINGH S, SINGH PP, SINGH AG, et al.Anti-diabetic medications and risk of pancreatic cancer in patients with diabetes mellitus:a systematic review and meta-analysis[J].Am J Gastroenterol, 2013, 108 (4) :510-519.

[27]LI D.Diabetes and pancreatic cancer[J].Mol Carcinog, 2012, 51 (1) :64-74.

[28]ZHOU L, ZHANG R, WANG L, et al.Upregulation of REG Ialpha accelerates tumor progression in pancreatic cancer with diabetes[J].Int J Cancer, 2010, 127 (8) :1795-1803.

[29]OSMAN MA, SARKAR FH, RODRIGUEZ-BOULAN E.A molecular rheostat at the interface of cancer and diabetes[J].Biochim Biophys Acta, 2013, 1836 (1) :166-176.

施引文献

资源附件(0)

访问统计