自噬在急性胰腺炎发生发展中的作用

杨淑丽; 刘洁; 陈卫昌

doi:10.3969/j.issn.1001-5256.2014.08.007

自噬在急性胰腺炎发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2014.08.007

1. 苏州卫生职业技术学院内科教研室
2. 苏州大学附属第一医院消化科

详细信息

中图分类号: R576
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出版历程
- 收稿日期: 2014-06-17
- 出版日期: 2014-08-20

Role of autophagy in development and progression of acute pancreatitis

Department of Internal Medicine, Suzhou Health College

摘要

摘要: 急性胰腺炎是胰酶提前激活造成胰腺及周围组织自身消化的一种急性炎症性疾病,自噬作为细胞清除异常物质的一种方式,出现在急性胰腺炎的早期病理过程中,其中自噬过程受损是其关键病理反应。自噬受损、组织蛋白水解酶失调、自噬调节异常提示自噬在急性胰腺炎中发挥重要作用。针对自噬形成、自噬与酶原激活、自噬受损与急性胰腺炎及自噬缺陷促进炎症发展等方面对自噬在急性胰腺炎中的作用进行探讨。
- 胰腺炎 /
- 胰蛋白酶原 /
- 自噬 /
- 炎症 /
- 综述
Abstract: Acute pancreatitis is considered an autodigestive disorder in which inappropriate activation of trypsinogen to trypsin within pancreatic acinar cells leads to the development of pancreatitis.Autophagy is an evolutionarily preserved degradation process of cytoplasmic cellular constituents, and it is one of the early pathological processes in acute pancreatitis.Autophagic flux is impaired in acute pancreatitis, which mediates the key pathologic responses of this disease.Impaired autophagy, dysfunction of lysosomes, and dysregulation of autophagy suggest a disorder of the endolysosomal pathway in acute pancreatitis.The role of autophagy in acute pancreatitis is discussed from the aspects of autophagic process, autophagy and activation of trypsinogen, impaired autophagy and acute pancreatitis, and defective autophagy promoting inflammation.
- pancreatitis /
- trypsinogen /
- autophagy /
- inflammation /
- review

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参考文献(27)

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