胆囊切除与非酒精性脂肪肝关系的初步探讨

黄耀彬; 李焕敏; 李春光

doi:10.3969/j.issn.1001-5256.2014.07.017

胆囊切除与非酒精性脂肪肝关系的初步探讨

DOI: 10.3969/j.issn.1001-5256.2014.07.017

1. 南方医科大学第三附属医院影像科
2. 南方医科大学第三附属医院神经内科
3. 南方医科大学珠江医院神经内科

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中图分类号: R575.5
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出版历程
- 收稿日期: 2014-03-31
- 出版日期: 2014-07-20

Association of cholecystectomy with non-alcoholic fatty liver

Department of Radiology, The Third Affiliated Hospital of Southern Medical University

摘要

摘要:
目的探讨人群中胆囊切除与非酒精性脂肪肝的关系。方法选用广州地区2011年1月-2013年12月在南方医科大学第三附属医院参加体检的110例胆囊切除患者为研究对象,均无病毒性肝炎和大量酒精摄入史。为明确非酒精性脂肪肝,所有患者均行CT扫描,并且检测血液中甘油三酯和胆固醇的水平。结果 110个胆囊切除患者中非酒精性脂肪肝的患病率为38.18%（42人）,其中男性的患病率为45.90%（28人）,女性的患病率为28.59%（14人）。所有入组对象中血脂升高者占70.91%（78人）,血脂正常者为29.09%（32人）。结论胆囊切除可能是非酒精性脂肪肝发病的一个危险因素。
- 胆囊切除术 /
- 非酒精性脂肪肝 /
- 体层摄影术,螺旋计算机
Abstract:
Objective To investigate the association of cholecystectomy with non- alcoholic fatty liver. Methods The 110 adults treated by cholecystectomy, who underwent physical examination in the Third Affiliated Hospital of Southern Medical University from January 2011to December 2013, were included in the study. None of the subjects had a history of viral hepatitis and alcohol abuse. All subjects underwent CT scanning and measurement of serum triglyceride and cholesterol levels to confirm the diagnosis of non- alcoholic fatty liver. Results Among the 110 subjects, 42 (38. 18%) had non- alcoholic fatty liver, including 28 males (45. 90%) and 14 females (28. 59%) ; 78 (70.91%) had increased blood lipids, and 32 (29.09%) had normal blood lipids. Conclusion Cholecystectomy may be a risk factor for NAFLD.
- cholecystectomy /
- non-alcoholic fatty liver /
- tomography, spriral computed

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参考文献(12)

[1]FAN JG.Differences and similarities of guidelines from China and abroad on the diagnosis and management including liver transplantation of nonalcoholic fatty liver disease[J].J Clin Hepatol, 2012, 28 (7) :493-495. (in Chinese) 范建高.国内外非酒精性脂肪性肝病诊疗指南的异同[J].临床肝胆病杂志, 2012, 28 (7) :493-495.

[2]Joint Committee for developing Chinese Guidelines for the management of dyslipidemia in adults.Chinese guidelines for the management of dyslipidemia adults[J].Chin J Cardiol, 2007, 35 (5) :390-419. (in Chinese) 中国成人血脂异常防治指南制订联合委员会.中国成人血脂异常防治指南[J].中华心血管病杂志, 2007, 35 (5) :390-419.

[3]PAMILO M, SOTANIEMI EA, SURAMO I, et al.Evaulation of liver steatotic and fibrous content by computerized tomography and ultrasound[J].Scand J Gastroenterol, 1983, 18 (6) :743-747.

[4]DONG S, LIU P, SUN MY.Role of“two-hit”in non-alcoholic fatty liver disease[J].J Clin Hepatol, 2012, 28 (7) :551-555. (in Chinese) 董姝, 刘平, 孙明瑜.非酒精性脂肪肝发病机制——“二次打击”学说研究进展[J].临床肝胆病杂志, 2012, 28 (7) :551-555.

[5]FORBES S, TAYLOR-ROBINSON SD, PATEL N, et al.Increased prevalence of non-alcoholic fatty liver disease in European women with a history of gestational diabetes[J].Diabetologia, 2011, 54 (3) :641-647.

[6]RUHL CE, EVERHART JE.Relationship of non-alcoholic fatty liver disease with cholecystectomy in the US population[J].Am J Gastroenterol, 2013, 108 (6) :952-958.

[7]AMIGO L, HUSCHE C, ZANLUNGO S, et al.Cholecystectomy increases hepatic triglyceride content and very-low-density lipoproteins production in mice[J].Liver Int, 2011, 31 (1) :52-64.

[8]KULLAK-UBLICK GA, PAUMGARTNER G, BERR F.Longterm effects of cholecystectomy on bile acid metabolism[J].Hepatology, 1995, 21 (1) :41-45.

[9]LEFEBVRE P, CARIOU B, LIEN F, et al.Role of bile acids and bile acid receptors in metabolic regulation[J].Physiol Rev, 2009, 89 (1) :147-191.

[10]TRAUNER M, CLAUDEL T, FICKERT P, et al.Bile acids as regulators of hepatic lipid and glucose metabolism[J].Dig Dis, 2010, 28 (1) :220-224.

[11]JONES S.Mini-review:endocrine actions of fibroblast growth factor19[J].Mol Pharm, 2008, 5 (1) :42-48.

[12]EREN F, KURT R, ERMIS F, et al.Preliminary evidence of a reduced serum level of fibroblast growth factor 19 in patients with biopsy-proven nonalcoholic fatty liver disease[J].Clin Biochem, 2012, 45 (9) :655-658.

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