HBV/HCV重叠感染的研究进展

何丽; 胡萍; 申焕君; 张野; 黄长形

doi:10.3969/j.issn.1001-5256.2014.06.024

HBV/HCV重叠感染的研究进展

DOI: 10.3969/j.issn.1001-5256.2014.06.024

第四军医大学唐都医院传染科

基金项目:

国家自然科学基金资助项目(81072434)；国家“十一五”科技重大专项(2008ZX10002-006)；

详细信息

中图分类号: R512.62;R512.63
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- 被引次数: 0
出版历程
- 收稿日期: 2014-02-10
- 出版日期: 2014-06-20

Research progress in HBV /HCV co- infection

Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University

Research funding:

摘要

摘要: HBV是一种嗜肝DNA病毒,HBV DNA和HBV特异P蛋白由核壳包裹成为核心颗粒,再由脂蛋白外膜包裹成完整的病毒颗粒。HCV是黄病毒科病毒,为单股正链RNA。HBV和HCV均由肠道外途径传播,2种病毒常可由相同途径发生感染。归纳了HBV/HCV重叠感染的发病机制、与隐匿性HBV感染和肝细胞癌以及器官移植、HBV疫苗之间的关系,同时介绍了重叠感染的治疗。指出存在于患者体内的HBV和HCV在病毒学方面相互干扰,在病变方面相互叠加。
- 乙型肝炎病毒 /
- 丙型肝炎病毒 /
- 重叠感染 /
- 乙型综述
Abstract: Hepatitis B virus ( HBV) is a hepatotropic DNA virus; HBV DNA and special P protein are covered by capsid proteins to form core particles, which are then covered by lipoprotein to form complete virus particles. Hepatitis C virus ( HCV) , which belongs to the Flaviviridae family, is a single- stranded, positive- sense RNA. HBV and HCV are transmitted by parenteral route and may cause co- infection through the same route of transmission. The pathogenesis of HBV /HCV co- infection and its relationship with occult HBV infection, hepatocellular carcinoma, organ transplantation, and HBV vaccine are reviewed. Meanwhile, the treatment of co- infection is presented. It is shown that HBV and HCV interfere with each other in terms of virology and pathology.
- hepatitis B virus /
- hepatitis C virus /
- superinfection /
- review

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参考文献(28)

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