异甘草酸镁治疗重度戊型黄疸性肝炎患者的疗效观察

罗小克; 李小玲; 杨立明; 王晓红

doi:10.3969/j.issn.1001-5256.2014.06.014

异甘草酸镁治疗重度戊型黄疸性肝炎患者的疗效观察

DOI: 10.3969/j.issn.1001-5256.2014.06.014

1. 解放军第313医院感染科
2. 解放军91851部队

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出版历程
- 收稿日期: 2013-05-25
- 出版日期: 2014-06-20

Efficacy of magnesium isoglycyrrhizinate in treatment of hepatitis E with severe jaundice

Department of Infectious Diseases, 313 Hospital of PLA

摘要

摘要: 目的分析观察异甘草酸镁治疗戊型肝炎重度黄疸的疗效。方法选择2009年1月至2012年12月收治的戊型肝炎重度黄疸患者78例,同比例分为治疗组和对照组,每组各39例,2组均给予多烯磷脂酰胆碱、还原型谷胱甘肽、能量合剂保肝,治疗组加用异甘草酸镁注射液150 mg静滴,1次/d,而对照组则加用复方甘草酸苷注射液120 mg静滴1次/d,两组疗程均为6周。TBil<85μmol/L,ALT<160 U/L为主要有效指标。两组间均数采用成组t检验,组内治疗前后比较采用配对t检验,计数资料组间比较用χ2检验。结果两组患者治疗后均有好转,治疗组的总有效率为84.6%(33/39),优于对照组66.7%(26/39),差异有统计学意义(P<0.05)。且治疗组的TBil为(68.9±40.3)μmol/L,恢复显著优于对照组(129.1±69.3)μmol/L,其中各组F值为:24.658、36.145,χ2值为12、15,P<0.01,差异有统计学意义。结论异甘草酸镁治疗戊型肝炎重度黄疸疗效显著,一定药物浓度范围内对肝细胞增殖有明显的促进作用,加速黄疸消退,无明显不良反应。
- 戊型肝炎 /
- 黄疸 /
- 异甘草酸镁
Abstract: Objective To observe and analyze the efficacy of magnesium isoglycyrrhizinate in the treatment of hepatitis E with severe jaundice. Methods Seventy- eight cases of hepatitis E with severe jaundice admitted from January 2009 to December 2012 were equally divided into treatment group ( n = 39) and control group ( n = 39) . Both groups were given polyene phosphatidylcholine, reduced glutathione, and Adenosine Disodiu for liver protection; additionally, magnesium isoglycyrrhizinate injection ( 150 mg) was given to the treatment group by intravenous drip once daily, while compound glycyrrhizin injection ( 120 mg) was given to the control group by intravenous drip once daily. The course of treatment was 6 weeks in the two groups. Patients were considered to show response to treatment if their serum levels of total bilirubin ( TBil) and alanine aminotransferase were < 85 μmol /L and < 160 U /L, respectively. Comparison of means between the two groups was made by independent- samples t test; before- after comparison within each group was made by paired t- test; comparison of enumeration data between the two groups was made by chi- square test. Results Both groups showed improvements after treatment. The treatment group had a significantly higher overall response rate than the control group ( 84. 6% vs 66. 7%, P < 0. 05) . After treatment, the treatment group had a serum TBil level of 68. 9 ± 40. 3 μmol /L, with significantly more improvement compared with the serum TBil level for control group ( 129. 1 ± 69. 3 μmol /L) ( F = 24. 658, χ2= 12, P < 0. 01; F = 36. 145, χ2= 15, P < 0. 01) . Conclusion Magnesium isoglycyrrhizinate has significant efficacy in the treatment of hepatitis E with severe jaundice. It shows a marked promotional effect on the proliferation of liver cells within a certain concentration range, accelerates jaundice disappearance, and has no obvious adverse effects.
- hepatitis E /
- jaundice /
- magnesium isoglycyrrhizinate

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参考文献(13)

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