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江苏地区汉族人群白细胞介素28B基因多态性与丙型肝炎易感性的关系

谈国蕾 孙梅 王建芳 吴旭平

引用本文:
Citation:

江苏地区汉族人群白细胞介素28B基因多态性与丙型肝炎易感性的关系

DOI: 10.3969/j.issn.1001-5256.2014.06.009
基金项目: 

南京市医学科技发展资金资助(YKK13151,QRX11236); 

详细信息
  • 中图分类号: R512.63

Relationship between IL- 28B polymorphisms and susceptibility to hepatitis C among Han population in Jiangsu Province, China

Research funding: 

 

  • 摘要: 目的探讨江苏地区汉族人群白细胞介素(IL)28B基因多态性分布及其与丙型肝炎易感性的关系。方法选取2011年南京市第二医院就诊的丙型肝炎患者88名,体检中心健康体检的健康人群100例。应用聚合酶链式反应(PCR)和直接测序法检测丙型肝炎患者和健康人群IL-28B rs8099917、rs12979860、rs12980275、rs8113007和rs12972991位点的单核苷酸多态性(SNP),并统计分析这些位点的基因型和等位基因在两种不同人群中分布的差异。采用Pearsonχ2检验进行分析,计算Hardy-Weinberg遗传平衡以判断样本的代表性。结果两者间性别和年龄差异均无统计学意义(P=0.92、0.28),在检测人群中IL-28B基因5个位点的主要基因型分别是TT、CC、AA、AA、AA;丙型肝炎患者IL-28B基因SNP位点与健康人群在基因型(χ2=0.31、0.50、0.60、0.15、0.07,P均>0.05)和等位基因(χ2=0.29、0.48、0.56、0.14、0.07,P均>0.05)分布上差异均无统计学意义。结论 IL-28B的SNPs位点(rs...

     

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  • 收稿日期:  2014-01-09
  • 出版日期:  2014-06-20
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