110例丙型肝炎患者流行病学特征和疾病谱分析

黄燕武; 韩凤娟

doi:10.3969/j.issn.1001-5256.2014.06.007

110例丙型肝炎患者流行病学特征和疾病谱分析

DOI: 10.3969/j.issn.1001-5256.2014.06.007

解放军第536医院传染科

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中图分类号: R512.63
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出版历程
- 收稿日期: 2013-07-05
- 出版日期: 2014-06-20

Epidemiological features and disease spectrum of hepatitis C in Qinghai Province, China: analysis of 110 cases

Department of Infectious Diseases, 536 Hospital of PLA

摘要

摘要: 目的调查丙型肝炎住院患者的流行病学特征和疾病谱,为HCV感染的防治提供参考。方法回顾性分析2008年1月至2011年10月住院的110例丙型肝炎患者的人口学、流行病学资料和实验室检查,计数资料的比较用χ2检验。结果在110例被调查的患者中,男∶女为1.2∶1;传播途径主要有应用血制品、手术、不明原因、静脉吸毒和性传播等。2008至2011年年发病人数分别为16、18、32、44人。本地区HCV基因型有1b、2a型,1b型最多占60.7%(17/28),其次为2a型占28.6%(8/28),1b/2a混合型占7.1%(2/28),3b型3.6%(1/28)。慢性肝炎占67.3%,肝硬化率达19.1%。结论 HCV年发病呈上升趋势,HCV基因分型以1b和2a为主,丙型肝炎易于向肝硬化发展,应加强重点人群疫情监测。
- 丙型肝炎 /
- 流行病学 /
- 基因型
Abstract: Objective To investigate the epidemiological features and disease spectrum of inpatients with hepatitis C in recent years and to provide reference for the control of hepatitis C. Methods A retrospective study of demography, epidemiology, and laboratory examination was performed in 110 hospitalized patients with hepatitis C. Results Of the 110 patients, 60 were male and 50 were female, with a male-to- female ratio of 1. 2: 1. The main transmission routes included blood product transfusion ( 33. 6%) , surgery ( 30. 0%) , intravenous drug use ( 14. 5%) , and sexual transmission ( 4. 5%) . The other 19 cases ( 17. 4%) were of unknown transmission route. The annual numbers of cases from 2008 to 2011 were 16, 18, 32, and 44, respectively. The genotype proportions in patients were as follows: 1b, 60. 7% ( 17 /28) ; 2a, 28. 6% ( 8 /28) ; 1b /2a mixed type, 7. 1% ( 2 /28) ; 3b, 3. 6% ( 1 /28) . Of all patients, 13. 6% ( 15 /110) were found with acute hepatitis C, 67. 3% ( 74 /110) with chronic hepatitis C, 19. 1% ( 21 /110) with liver cirrhosis, and 10. 9% ( 12 /110) with decompensated cirrhosis. Conclusion The incidence of HCV infection has been increasing year by year. The major HCV genotypes are 1b and2a. Hepatitis C is apt to develop into liver cirrhosis. It is necessary to reinforce monitoring and to carry out specific epidemiological study among the target population.
- hepatitis C /
- epidemiology /
- genotype

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