慢性乙型肝炎患者HBV DNA载量与ALT水平的相关性分析

冯广帅; 潘玲; 冯全生

doi:10.3969/j.issn.1001-5256.2014.05.009

慢性乙型肝炎患者HBV DNA载量与ALT水平的相关性分析

DOI: 10.3969/j.issn.1001-5256.2014.05.009

成都中医药大学

基金项目:

“十二五”国家科技重大专项资助项目(2012ZX10005001)；

详细信息

中图分类号: R512.62
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出版历程
- 收稿日期: 2013-10-08
- 出版日期: 2014-05-20

Correlation between HBV DNA load and ALT level: analysis of 800 patients with chronic hepatitis B

Chengdu University of Traditional Chinese Medicine

Research funding:

摘要

摘要: 目的分析HBV DNA载量与ALT水平的关系,探讨HBV感染时ALT发生变化的原因。方法以ALT值作为因变量,以HBV DNA作为自变量,应用SPSS 16.0软件对指标进行曲线拟合,建立曲线回归方程后对曲线方程进行分析。结果通过软件分析建立幂模型:R2=0.107,F=85.887,P=0.000,b0=47.785,b1=0.075,b2=0。分析曲线发现随着HBV DNA载量的增加,ALT的值持续升高,但升高幅度越来越小;当HBV DNA载量达到一定范围后,随着HBV DNA载量的增加,ALT的值变化幅度极小,并无限接近某一特定值。结论 ALT的变化与HBV DNA载量有相关性,但HBV DNA可能不是导致ALT值发生变化的最直接的原因。
- 肝炎,乙型,慢性 /
- 肝炎病毒,乙型 /
- 丙氨酸转氨酶 /
- 线性模型
Abstract: Objective To analyze the relationship between hepatitis B virus ( HBV) DNA load and serum alanine aminotransferase ( ALT) level and to investigate the reason that ALT level changes in patients with HBV infection. Methods ALT level ( dependent variable) and HBV DNA load ( independent variable) were subjected to curve fitting using SPSS 16. 0 to establish a curve regression equation and analyze the curve regression equation. Results A power model was established by software analysis, with the following results: R2= 0. 107, F = 85. 887, P = 0. 000, b0= 47. 785, b1= 0. 075, b2= 0. The curve analysis showed that as the HBV DNA load increased, the ALT level kept rising, but at a decreasing rate; within a certain range, the increase in HBV DNA load led to little change in ALT level, which was infinitely close to a certain value. Conclusion ALT level is correlated with HBV DNA load, but HBV DNA may not be the most direct cause of change in ALT level.
- hepcotitis B, chronic /
- hepatitis B virus /
- alanine transaminase /
- linear models

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参考文献(12)

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