HBV感染者HBsAg和抗-HBs双阳性发生机制

任美欣; 孟庆华

doi:10.3969/j.issn.1001-5256.2014.04.023

HBV感染者HBsAg和抗-HBs双阳性发生机制

DOI: 10.3969/j.issn.1001-5256.2014.04.023

首都医科大学附属北京佑安医院重症肝病科

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中图分类号: R512.62
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出版历程
- 出版日期: 2014-04-20

Research progress in mechanism of coexistence of HBsAg and HBsAb in patients with HBV infection

Department of Severe Liver Disease, Beijing Youan Hospital, Capital Medical University

摘要

摘要:
HBV感染后可产生一种保护性抗体抗-HBs,是病毒清除的典型特征。乙型肝炎表面抗原（HBsAg）和抗-HBs序贯表达,理论上在同一患者不可能同时检出。但是近年来,关于HBsAg和抗-HBs同时阳性的报道屡见不鲜。在临床中,HBsAg和抗-HBs同时阳性的现象多见于慢性乙型肝炎患者,及注射乙型肝炎疫苗或使用大剂量单克隆抗-HBs的患者。对于这种特殊现象的发生机制尚不清楚。总结了国内外相关研究结果,分析表明HBsAg和抗-HBs双阳性可能与HBV S基因变异和抗-HBs结合力下降等有关。
- 肝炎,乙型,慢性 /
- 肝炎表面抗原,乙型 /
- 综述
Abstract:
Hepatitis B surface antibody (HBsAb) is formed in response to hepatitic B virus (HBV) infection, which is a typical characteristic of virus clearance.It is theoretically impossible to detect sequential expression of hepatitis B surface antigen (HBsAg) and HBsAb in the same patient.In recent years, however, cases of coexistence of HBsAg and HBsAb have been frequently reported.Clinically, coexistence of HBsAg and HBsAb is commonly seen in patients with chronic hepatitis B and those injected with hepatitis B vaccine or given high-dose monoclonal anti- HBs.The mechanism of this special phenomenon remains unclear.The relevant research findings in China and the rest of the world are summarized.Analysis shows that coexistence of HBsAg and HBsAb may be related to HBV S gene mutation, decreased binding force of HBsAb, etc.
- hepatitis B, chronic /
- hepatitis B surface antigens /
- review

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参考文献(42)

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