恩替卡韦联合心肝宝胶囊治疗慢性乙型肝炎肝硬化的疗效观察

高远征; 贾素华; 赵连峰; 姜英; 王妍

doi:10.3969/j.issn.1001-5256.2014.04.007

恩替卡韦联合心肝宝胶囊治疗慢性乙型肝炎肝硬化的疗效观察

DOI: 10.3969/j.issn.1001-5256.2014.04.007

滨州市中心医院感染科

详细信息

中图分类号: R575.2
计量
- 文章访问数: 3053
- HTML全文浏览量: 23
- PDF下载量: 612
- 被引次数: 0
出版历程
- 收稿日期: 2014-02-07
- 出版日期: 2014-04-20

Clinical efficacy of entecavir combined with Xinganbao capsules in treatment of liver cirrhosis among patients with chronic hepatitis B

Department of Infectious Diseases, Binzhou Central Hospital

摘要

摘要:
目的观察恩替卡韦联合心肝宝治疗慢性乙型肝炎肝硬化的临床疗效。方法将本院2010年5月-2013年10月收治的60例慢性乙型肝炎肝硬化患者随机分为2组,治疗组（30例）给予恩替卡韦联合心肝宝胶囊治疗,对照组（30例）只给与恩替卡韦治疗,疗程均为6个月。观察2组治疗前后肝功能、血清纤维化指标和肝、脾影像学等项目。计量资料组间比较采用t检验,计数资料组间比较采用χ2检验。结果治疗组ALT、AST与对照组相比差异有统计学意义（P<0.05）,血清纤维化指标,肝、脾影像学检查有显著改善（P<0.01）。结论恩替卡韦联合心肝宝治疗慢性乙型肝炎肝硬化,具有改善肝功能,减轻肝组织炎症;抗肝纤维化,降低门静脉压力和缩脾作用。
- 肝炎,乙型,慢性 /
- 肝硬化 /
- 恩替卡韦 /
- 心肝宝胶囊
Abstract:
Objective To observe the clinical efficacy of entecavir combined with Xinganbao capsules in the treatment of liver cirrhosis among patients with chronic hepatitis B (CHB) .Methods Sixty CHB patients with liver cirrhosis were randomly divided into two groups:treatment group (n = 30) given entecavir combined with Xinganbao capsules and control group (n = 30) given entecavir alone.The course of treatment was 6 months.The treatment outcomes were evaluated based on liver function, serum fibrosis markers, and imaging findings of the liver and spleen.Comparison of continuous data between groups was made by t test, while comparison of categorical data was made by chi- square test.Results After treatment, the treatment group had significantly lower serum levels of alanine aminotransferase and aspartate aminotransferase (P < 0.05) , significantly reduced serum fibrosis markers (P < 0.01) , and significantly improved imaging findings of the liver and spleen (P < 0.01) , as compared with the control group.Conclusion Entecavir combined with Xinganbao capsules can improve liver function, reduce hepatic inflammation and fibrosis, and decrease portal pressure and spleen thickness in the treatment of liver cirrhosis among CHB patients.
- hepatitis B, chronic /
- liver cirrhosis /
- entecavir /
- Xinganbao capsule

HTML全文

参考文献(11)

[1]Chinese Society of Infectious Diseases and Parasitology, Chinese Society of Hepatology, Chinese Medical Association.Diagnosis and treatment of viral hepatitis[J].Chin J Integr Tradit West Med Liver Dis, 2001, 11 (1) :56-60. (in Chinese) 中华医学会传染病与寄生虫病学分会, 肝病学分会.病毒性肝炎的诊断标准[J].中西医结合肝病杂志, 2001, 11 (1) :56-60.

[2]Chinese Society of Hepatology, Chinese Society of Infectious Diseases, Chinese Medical Association.The guideline for prevention and treatment of chronic hepatitis B[J].J Clin Hepatol, 2006, 22 (1) :3-15. (in Chinese) 中华医学会肝病学分会, 中华医学会感染病学分会.慢性乙型肝炎防治指南[J].临床肝胆病杂志, 2006, 22 (1) :3-15.

[3]HOU JL.Entecavir:a new option for treatment of chronic hepatitis B[J].Chin Hepatol, 2005, 10 (2) :164-166. (in Chinese) 候金林.恩替卡韦:慢性乙型肝炎治疗的新选择[J].肝脏, 2005, 10 (2) :164-166.

[4]Committee of experts on antiviral therapy of chronic hepatitis B.Experts consensus on antiviral therapy of chronic hepatitis B[J].J Clin Hepatol, 2010, 26 (2) :125-130. (in Chinese) 慢性乙型肝炎抗病毒治疗专家委员会.慢性乙型肝炎抗病毒治疗专家共识[J].临床肝胆病杂志, 2010, 26 (2) :125-130.

[5]SHAMN A, CHU CK.Understanding the molecular basis of HBV resistance by molecular modeling[J].Antivir Res, 2008, 80 (3) :339-352.

[6]LOK AS, McMAHON BJ.Chronic haipaititis B:update 2009[J].Hepatology, 2009, 50 (30) :661-662.

[7]European Association for the study of the liver.EASL clinical practice guidelines:management of chrotitis B[J].J Hepatol, 2009, 50 (3) :661-662.

[8]GU ZY, WENG HL, CAI WM, et al.Clinical value of serum fibrosis markers in patients with chronic hepatitis[J].J Clin Hepatol, 2000, 16 (3) :171-173. (in Chinese) 顾竹影, 翁红雷, 蔡卫民, 等.探讨慢性肝炎患者血清纤维化指标的临床价值[J].临床肝胆病杂志, 2000, 16 (3) :171-173.

[9]WANG XB, JIANG YY, ZHAO CY, et al.Clinical research of Xinganbao capsule on the treatment of chronic hepatitis B liver fibrosis[J].Chin J Integr Tradit West Med, 2012, 32 (3) :325-328. (in Chinese) 王宪波, 江宇泳, 赵彩彦, 等.心肝宝胶囊治疗慢性乙型肝炎肝纤维化临床研究[J].中国中西医结合杂志, 2012, 32 (3) :325-328.

[10]WANG XB, LIU P, TANG ZP.Intervening and Therapeutic Effect of Cordyceps Mycelia Extract on Liver Cirrhosis Induced by Dimethylnitrosamine in Rats[J].Chin J Integr Tradit West Med, 2008, 28 (7) :617-623. (in Chinese) 王宪波, 刘平, 唐志鹏.虫草菌丝提取物干预与治疗二甲基亚硝胺诱导大鼠肝硬化的实验研究[J].中国中西医结合杂志, 2008, 28 (7) :617-623.

[11]WANG XB, LIU P, TANG ZP.Cordyceps mycelia extract decreases portal hypertension in rats with dimethylnitrosamin-induced liver cirrhosis:a study on its histological basis[J].J Chin Integr Med, 2008, 6 (11) :1136-1144. (in Chinese) 王宪波, 刘平, 唐志鹏.冬虫夏草菌丝提取物降低二甲基亚硝胺大鼠肝硬化门静脉高压效应的组织学基础[J].中西医结合学报, 2008, 6 (11) :1136-1144.

施引文献

资源附件(0)

访问统计