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中晚期肝癌临床治疗进展

李焱 程朋

引用本文:
Citation:

中晚期肝癌临床治疗进展

DOI: 10.3969/j.issn.1001-5256.2014.03.009
详细信息
  • 中图分类号: R735.7

Advances in treatment of advanced hepatocellular cancer

  • 摘要:

    肝癌的发病隐匿,早期诊断困难,进展较快,临床上仅有不足30%的患者就诊时可获得手术治疗的机会,因此非手术疗法是中晚期肝癌的主要治疗方式。总结了几种主要的非手术治疗方式———血管介入治疗、分子靶向和化疗药物治疗、放疗以及局部消融治疗在肝癌治疗中的地位。认为尽管综合治疗已成为肝癌治疗的共识,但是他们在综合治疗中的地位及次序等仍未形成共识,还需要进行更多的临床研究,从而为中晚期肝癌患者的治疗提供更好的选择。

     

  • [1]CHOI JW, PARK JY, AHN SH, et al.Efficacy and safety of transarterial chemoembolization in recurrent hepatocellular carcinoma after curative surgical resection[J].Am J Clin Oncol, 2009, 32 (6) :564-549.
    [2]LLOVET JM, REAL MI, MONTANA X, et al.Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma:a randomised controlled trial[J].Lancet, 2002, 359:1734-1739.
    [3]CAMMO C, SCHEPIS F, ORLANDO A, et al.Transarterial chemoembolization for unresectable hepatocellular carcinoma:meta-analysis of randomized controlled trials[J].Radiology, 2002, 224 (1) :47-54.
    [4]BEFELER AS.Chemoembolization and bland embolization:a critical appraisal[J].Clin Liver Dis, 2005, 9 (2) :287-300.
    [5]TAKAYASU K, ARII S, KUDO M, et al.Superselective transarterial chemoembolization for hepatocellular carcinoma.Validation of treatment algorithm proposed by Japanese guidelines[J].J Hepatol, 2012, 56 (4) :886-892.
    [6]LO CM, NGAN H, TSO WK, et al.Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma[J].Hepatology, 2002, 35 (5) :1164-1171.
    [7]SANGRO B, BIBAO JI, BOAN J, et al.Radioembolization using90Y-resin microspheres for patients with advanced hepatocellular carcinoma[J].Int J Radiat Oncol Biol Phys, 2006, 66 (3) :792-800.
    [8]SANGRO B, CARPANESE L, CIANNI R, et al.Survival after yttrium-90 resin microsphere radioembolization of hepatocellular carcinoma across barcelona clinic liver cancer stages:a european evaluation[J].Hepatology, 2011, 54 (3) :868-878.
    [9]CARR BI, KONDRAQUNTA V, BUCH SC, et al.Therapeutic equivalence in survival for hepatic arterial chemoembolization and yttrium 90 microspheres treatments in unresectable hepatocellular carcinoma:a two-cohort study[J].Cancer, 2010, 116 (5) :1305-1314.
    [10]LAMMER J, MALAGARI K, VOGL T, et al.Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma:results of the PRECISION V study[J].Cardiovasc Intervent Radiol, 2010, 33 (1) :41-52.
    [11]LOVET JM, RICCI S, MAZZAFERRO V, et al.Sorafenib in advanced hepatocellular carcinoma[J].N Engl J Med, 2008, 359 (4) :378-390.
    [12]CHENG AL, KANG YK, CHEN Z, et al.Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma:a phase III randomised, double-blind, placebocontrolled trial[J].Lancet Oncol, 2009, 10 (1) :25-34.
    [13]RICHLY H, KUPSCH P, PASSAGE K, et al.Results of a phase I trial of BAY 43-9006 in combination with doxorubicin in patients with primary hepatic cancer[J].Int J Clin Pharmacol Ther, 2004, 42 (11) :650-651.
    [14]DEL PRETE S, MONTELLA L, ADDED R, et al.Sorafenib plus long acting octreotide in advanced hepatocellular carcinoma.Preliminary results of a multicenter ongoing study[J].J Clin Oncol, 2008, 26 (19) :15624.
    [15]MOORE M, HIRTE HW, SIU L, et al.Phase I study to determine the safety and pharmacokinetics of the novel Raf kinase and VEGFR inhibitor BAY 43-9006, administered for 28 days on/7 days off in patients with advanced, refractory solid tumors[J].Ann Oncol, 2005, 16 (10) :1688-1694.
    [16]STRUMBERG D, VOLIOTIS D, MOELLER JG, et al.Results of phase I pharmacokinetic and pharmacodynamic studies of the Raf kinase inhibitor BAY 43-9006 in patients with solid tumors[J].Int J Clin Pharmacol Ther, 2002, 40 (12) :580-581.
    [17]FORNER A, LLOVET JM, BRUIX J.Sunitinib and the benefits of a negative study[J].Lancet Oncol, 2009, 10 (8) :743-744.
    [18]GONG XL, QIN SK, WANG YJ, et al.Effcicacy of FOLFOX4 regimen in treatment of advanced hepatocellular carcinoma:a multicenter phaseⅡtrial[J].Chin J New Drugs, 2011, 20 (17) :1673-1677. (in Chinese) 龚新雷, 秦叔逵, 王雅杰, 等.FOLFOX4方案治疗晚期肝细胞癌的多中心Ⅱ期临床研究[J].中国新药杂志, 2011, 20 (17) :1673-1677.
    [19]LIANG SX, ZHU XD, LU HJ, et al.Hypofractionated three-dimensional conformal radiation therapy for primary liver carcinoma[J].Cancer, 2005, 103 (10) :2181-2188.
    [20]JANG JW, KAY CS, YOU CR, et al.Simultaneous multitarget irr adiation using helical tomotherapy for advanced hepatocellular carcinoma with multiple extrahepatic metastases[J].Int J Radiat Onco l Biol Phys, 2009, 74 (2) :412-418.
    [21]KWON JH, BAE SH, KIM JY, et al.Long-term effect of stereotactic body radiation therapy for primary hepatocellular carcinoma ineligible for local ablation therpy or surgical resection.Stereotactic radiothreapy for liver cancer[J].BMC Cancer, 2010, 10:475.
    [22]MIZUMOTO M, TOKUUYE K, SUGAHARA S, et al.Proton beam therapy for hepatocellular carcinoma with inferior vena cava tumor thrombus:report of three cases[J].Jpn J Clin Onco l, 2007, 37 (6) :459-462.
    [23]TAURA K, IKAI I, HATANO E, et al.Implication of frequent local ablation therapy for intrahepatic recurrence in prolonged survival of patients with hepatocellular carcinoma undergoing hepatic resection:an analysis of 610 patients over 16 years old[J].Ann Surg, 2006, 244 (2) :265-273.
    [24]CHOI D, LIM HK, RHIM H, et al.Percutaneous radiofrequency ablation for recurrent hepatocellular carcinoma after hepatectomy:long-term results and prognostic factors[J].Ann Surg Oncol, 2007, 14 (8) :2319-2329.
    [25]LIANG HH, CHEN MS, PENG ZW, et al.Percutaneous radiofrequency ablation versus repeat hepatectomy for recurrent hepatocellular carcinoma:a retrospective study[J].Ann Surg Oncol, 2008, 15 (12) :3484-3493.
    [26]GOTO E, TATEISHI R, SHIINA S, et al.Hemorrhagic complications of percutaneous radiofrequency ablation for liver tumors[J].Clin Gastroenterol, 2010, 44 (5) :374-380.
    [27]BECKER G, SOEZGEN T, OLSCHEWSKI M, et al.Combined TACE and PEI for palliative treatment of unresectable hepatocellular carcinoma[J].World J Gastroenterol, 2005, 11 (39) :6104-6109.
    [28]ZHANG YJ, LIANG HH, CHEN MS, et al.Hepatocellularcarcinoma treated with radio frequency ablation with or without ethanol injection:a pro spective randomizedtrial[J].Radiology, 2007, 244 (2) :599-607.
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  • 出版日期:  2014-03-20
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