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因子V Leiden突变在布加综合征与门静脉血栓形成中的意义

胡凤蓉 高帆 杨庆 祁兴顺

引用本文:
Citation:

因子V Leiden突变在布加综合征与门静脉血栓形成中的意义

DOI: 10.3969/j.issn.1001-5256.2014.01.025
基金项目: 

国家自然科学基金(81100267); 

详细信息
  • 中图分类号: R575.3

Significance of factor V Leiden mutation in Budd- Chiari syndrome and portal vein thrombosis

Research funding: 

 

  • 摘要: 布加综合征与门静脉血栓是2种罕见的肝脏血管病,可伴发肝功能衰竭及门静脉高压症等严重并发症。研究证据表明因子V Leiden(FVL)突变是西方布加综合征与门静脉血栓患者的重要危险因素,但在中国布加综合征患者中比较罕见。着重回顾FVL突变在布加综合征与门静脉血栓形成中的意义,提出尚须前瞻性研究进一步评估FVL突变在中国门静脉血栓患者中的患病率,以判断FVL突变筛查的必要性。

     

  • [1]de STEFANO V, MARTINELLI I.Splanchnic vein thrombosis:clinical presentation, risk factors and treatment[J].Intern Emerg Med, 2010, 5 (4) :487-494.
    [2]de LEVE LD, VALLA DC, GARCIA-TSAO G.Vascular disorders of the liver[J].Hepatology, 2009, 49 (5) :1729-1764.
    [3]GAO Y, JIA JD.2009 AASLD Vascular disorders of the liver practice guidelines[J].J Clin Hepatol, 2010, 26 (1) :9-13. (in Chinese) 高岩, 贾继东.2009年AASLD肝脏血管疾病诊疗指南要点[J].临床肝胆病杂志, 2010, 26 (1) :9-13.
    [4]WANG ZG, LI CM, LI Z, et al.Evolution and prospects of Budd-Chiari syndrome[J].J Clin Hepatol, 2011, 27 (2) :113-115. (in Chinese) 汪忠镐, 李春民, 李震, 等.布-加综合征的进展与展望[J].临床肝胆病杂志, 2011, 27 (2) :113-115.
    [5]ZHANG W, YU YZ.Application of multi-slice spiral CT angiography in the diagnosis and treatrnent of portal hypertension[J].Chin J Pract Intern Med, 2012, 32 (1) :72-74. (in Chinese) 张伟, 于永征.多排螺旋CT血管成像在门静脉高压诊治中的应用[J].中国实用内科杂志, 2012, 32 (1) :72-74.
    [6]QI X, HU F, YANG Z, et al.JAK2V617F mutation and myeloproliferative disorders in splanchnic vein thrombosis[J].Aliment Pharmacol Ther, 2011, 33 (4) :495-496.
    [7]QI X, ZHANG C, HAN G, et al.Prevalence of the JAK2V617F mutation in Chinese patients with Budd-Chiari syndrome and portal vein thrombosis:a prospective study[J].J Gastroenterol Hepatol, 2012, 27 (6) :1036-1043.
    [8]QI X, WU F, REN W, et al.Thrombotic risk factors in Chinese Budd-Chiari syndrome patients.An observational study with a systematic review of the literature[J].Thromb Haemost, 2013, 109 (5) :878-884.
    [9]QI X, HE C, HAN G, et al.Prevalence of paroxysmal nocturnal hemoglobinuria in Chinese patients with Budd-Chiari syndrome or portal vein thrombosis[J].J Gastroenterol Hepatol, 2013, 28 (1) :148-152.
    [10]QI X, DE STEFANO V, WANG J, et al.Prevalence of inherited antithrombin, protein C, and protein S deficiencies in portal vein system thrombosis and Budd-Chiari syndrome:A systematic review and meta-analysis of observational studies[J].J Gastroenterol Hepatol, 2013, 28 (3) :432-442.
    [11]BERTINA RM, KOELEMAN BP, KOSTER T, et al.Mutation in blood coagulation factor V associated with resistance to activated protein C[J].Nature, 1994, 369 (6475) :64-67.
    [12]EMMERICH J, ROSENDAAL FR, CATTANEO M, et al.Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism-pooled analysis of 8 case-control studies including2310 cases and 3204 controls.Study Group for Pooled-Analysis in Venous Thromboembolism[J].Thromb Haemost, 2001, 86 (3) :809-816.
    [13]BOEKHOLDT SM, BIJSTERVELD NR, MOONS AH, et al.Genetic variation in coagulation and fibrinolytic proteins and their relation with acute myocardial infarction:a systematic review[J].Circulation, 2001, 104 (25) :3063-3068.
    [14]DONAHUE BS, GAILANI D, HIGGINS MS, et al.Factor V Leiden protects against blood loss and transfusion after cardiac surgery[J].Circulation, 2003, 107 (7) :1003-1008.
    [15]de STEFANO V, CHIUSOLO P, PACIARONI K, et al.Epidemiology of factor V Leiden:clinical implications[J].Semin Thromb Hemost, 1998, 24 (4) :367-379.
    [16]DENNINGER MH, BELDJORD K, DURAND F, et al.BuddChiari syndrome and factor V Leiden mutation[J].Lancet, 1995, 345 (8948) :525-526.
    [17] MAHMOUD AE, WILDE JT, ELIAS E.Budd-Chiari syndrome and factor V Leiden mutation[J].Lancet, 1995, 345 (8948) :526-526.
    [18]LEVOIR D, EMMERICH J, ALHENC-GELAS M, et al.Portal vein thrombosis and factor V Arg 506 to Gln mutation[J].Thromb Haemost, 1995, 73 (3) :550-551.
    [19]DENNINGER MH, HELLEY D, VALLA D, et al.Prospective evaluation of the prevalence of factor V Leiden mutation in portal or hepatic vein thrombosis[J].Thromb Haemost, 1997, 78 (4) :1297-1298.
    [20]MAHMOUD AE, ELIAS E, BEAUCHAMP N, et al.Prevalence of the factor V Leiden mutation in hepatic and portal vein thrombosis[J].Gut, 1997, 40 (6) :798-800.
    [21]JANSSEN HL, MEINARDI JR, VLEGGAAR FP, et al.Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis:results of a case-control study[J].Blood, 2000, 96 (7) :2364-2368.
    [22]DENTALI F, GALLI M, GIANNI M, et al.Inherited thrombophilic abnormalities and risk of portal vein thrombosis.a meta-analysis[J].Thromb Haemost, 2008, 99 (4) :675-682.
    [23]FENG B, XU K, JIANG H, et al.Relationship between factor V Leiden mutation and Chinese Budd-Chiari syndrome and its clinical significance[J].Chin Med J, 2000, 80 (5) :354-357. (in Chinese) 冯博, 徐克, 姜宏, 等.Fv Leiden突变与我国汉族人布-加综合征的相关性及其临床意义[J].中华医学杂志, 2000, 80 (5) :354-357.
    [24]ZHENG H, LIAN JH, QI H, et al.FV Leiden and FIIG20210A mutations in patients with Budd-Chiari syndrome[J].J Zhengzhou Univ:Med Sci, 2005, 40 (3) :456-458. (in Chinese) 郑红, 连建华, 齐华, 等.布-加综合征患者FVLeiden, FIIG20210A突变检测[J].郑州大学学报:医学版, 2005, 40 (3) :456-458.
    [25]LIN GL, XU PQ, QI H, et al.A study on the correlations between pathogenesis of Budd-Chiari syndrome and Factor V Leiden and Factor II G20210A mutations[J].Chin J Gen Surg, 2006, 21 (4) :275-277. (in Chinese) 林国领, 许培钦, 齐华, 等.布加综合征与凝血因子V Leiden及凝血酶原基因G20210A突变的关系研究[J].中华普通外科杂志, 2006, 21 (4) :275-277.
    [26]YU CW, GAO Y, GENG XP, et al.The research on the mutation of coagulation factor V of diseased tissues in Budd-Chiari Syndrome[J].J Clin Surg, 2007, 15 (11) :743-745. (in Chinese) 余朝文, 高涌, 耿小平, 等.布加综合征病变组织因子V突变的研究[J].临床外科杂志, 2007, 15 (11) :743-745.
    [27]CHENG D, XU H, LU ZJ, et al.Clinical features and etiology of Budd-Chiari syndrome in Chinese patients:a single-center study[J].J Gastroenterol Hepatol, 2013, 28 (6) :1061-1067.
    [28]QI X, WANG J, REN W, et al.Familial Budd-Chiari syndrome in China:A systematic review of the literature[J].ISRN Hepatology, 2013, 2013 (2013) :1-7.
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  • 收稿日期:  2013-05-23
  • 出版日期:  2014-01-20
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