乙型肝炎病毒X蛋白在原发性肝癌中的作用

廖凯; 张雷达

doi:10.3969/j.issn.1001-5256.2014.01.023

乙型肝炎病毒X蛋白在原发性肝癌中的作用

DOI: 10.3969/j.issn.1001-5256.2014.01.023

廖凯,
张雷达

第三军医大学附属西南医院肝胆科

基金项目:

国家自然科学基金资助项目(81071979)；

详细信息

中图分类号: R735.7
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出版历程
- 收稿日期: 2013-04-18
- 出版日期: 2014-01-20

Role of hepatitis B virus X protein in development and progression of primary liver cancer

Department of Hepatobiliary Surgery, Southwest Hospital, The Third Military Medical University

Research funding:

摘要

摘要: 乙型肝炎病毒X蛋白(HBx)是一种由HBV X基因编码的多功能蛋白,参与调节基因转录、细胞信号转导、细胞增殖转化、细胞周期和细胞凋亡。目前HBx蛋白被认为在HBV诱发原发性肝癌的过程中发挥重要作用。介绍了HBx蛋白与癌基因、抑癌基因、细胞增殖、细胞凋亡、肝癌侵袭转移和肝癌干细胞的关系,探讨了HBx蛋白在肝癌发生发展中的作用。
- 肝炎病毒,乙型 /
- bcl-2相关X蛋白质 /
- 癌,肝细胞
Abstract: Hepatitis B virus ( HBV) X protein ( HBx) is a multifunctional protein encoded by HBV X gene. It plays a regulatory role in gene transcription, cell signal transduction, cell proliferation and transformation, cell cycle, and cell apoptosis. Currently, HBx is considered to play an important role in the development and progression of HBV- related hepatocellular carcinoma ( HCC) . The relationship of HBx with oncogene, antioncogene, cell proliferation, cell apoptosis, invasion and metastasis of liver cancer, and liver cancer stem cells is presented, and the role of HBx in the development and progression of HCC is reviewed.
- hepatitis B virus /
- bcl-2-associated X protein /
- carcinoma, hepatocellular

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参考文献(37)

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