非酒精性脂肪性肝炎临床检验指标与病理特点的关系

常彬霞; 滕光菊; 孙颖; 赵军; 张伟; 霍丹丹; 郑瑞丹; 邹正升; 李保森

doi:10.3969/j.issn.1001-5256.2013.11.010

非酒精性脂肪性肝炎临床检验指标与病理特点的关系

DOI: 10.3969/j.issn.1001-5256.2013.11.010

1. 解放军第302医院非感染肝病诊疗中心
2. 江苏省泗洪县人民医院感染科
3. 解放军175医院

详细信息

中图分类号: R575.5
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出版历程
- 收稿日期: 2013-01-31
- 出版日期: 2013-11-20

Relationship between laboratory parameters and liver pathology in patients with nonalcoholic steatohepatitis

Center for Non-Infectious Liver Diseases, 302 Hospital of PLA

摘要

摘要: 目的探讨非酒精性脂肪性肝炎（NASH）患者的临床检验指标与病理特点之间的关系,以期能为该病的临床诊断与预后提供信息。方法回顾性分析2008年5月至2011年12月本院收治的206例经肝组织学检查确诊的NASH患者的临床资料,并对ALT、AST等检验指标以及肝穿刺病理结果等相关资料进行统计学分析。不同程度的脂肪变性、炎症和肝纤维化间的检测采用独立样本的t检验或者单因素方差分析,相关性分析采用Spearman分析。结果 ALT、AST、乳酸脱氢酶（LDH）对于判断肝脂肪变性、炎症及纤维化3种病理改变程度均具有统计学意义（P均<0.05）;白细胞（WBC）、碱性磷酸酶（ALP）对于判断肝脂肪变性及纤维化程度具有统计学意义（均为P<0.05）;平均红细胞体积（MCV）、血小板（PLT）、白蛋白（Alb）、胆碱酯酶（CHE）、γ-球蛋白电泳（γ-EP）、葡萄糖（Glu）对于判断肝脂肪变性程度具有统计学意义（P均<0.05）;不同的肝脂肪变性程度与炎症程度、纤维化程度,不同的炎症程度与纤维化程度之间均有相关性（相关系数分别为0.261、0.561、0.353,P均<0.05...
- 脂肪肝 /
- 病理学,临床 /
- 实验室技术和方法
Abstract: Objective To investigate the relationship between laboratory parameters and pathological features of the liver in patients with nonalcoholic steatohepatitis ( NASH) and to provide some information for the diagnosis and prognosis of NASH. Methods A retrospective analysis was performed on the clinical data of 206 patients with a histological diagnosis of NASH who were admitted to our hospital from May2008 to December 2011. Laboratory parameters such as alanine aminotransferase ( ALT) and aspartate aminotransferase ( AST) and liver pathology were analyzed statistically. The data on varying degrees of steatosis, inflammation, and fibrosis of the liver were analyzed using the independent- samples t test or one- way analysis of variance, and correlations were determined by Spearman analysis. Results There were significant differences in ALT, AST, and lactate dehydrogenase ( LDH) between patient groups with different degrees of steatosis, inflammation, or fibrosis ( P < 0. 05 for all) , significant differences in white blood cell ( WBC) and alanine phosphatase ( ALP) between patients groups with different degrees of steatosis or fibrosis ( P < 0. 05 for all) , and significant differences in mean corpuscular volume ( MCV) , platelet ( PLT) , albumin ( Alb) , cholinesterase ( CHE) , gamma globulin electrophoresis ( γ- EP) , and glucose ( Glu) between patient groups with different degrees of steatosis ( P < 0. 05 for all) . Correlations existed between the degrees of steatosis and inflammation, between the degrees of steatosis and fibrosis, and between the degrees of inflammation and fibrosis ( r = 0. 261, P < 0. 05; r = 0. 561, P < 0. 05; r =0. 353, P < 0. 05) . Conclusion ALT, AST, and LDH are significantly correlated with the degrees of steatosis, inflammation, and fibrosis, WBC and ALP are significantly correlated with the degrees of steatosis and fibrosis, and MCV, PLT, Alb, CHE, γ- EP, and Glu are significantly correlated with the degree of steatosis.
- fatty liver /
- pathology, clinical /
- laboratory techniques and procedures

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参考文献(1)

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