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RhoA在肝纤维化中的作用机制

洪金妮 安海燕

引用本文:
Citation:

RhoA在肝纤维化中的作用机制

DOI: 10.3969/j.issn.1001-5256.2013.08.023
基金项目: 

广东省中医药局2011年立项课题(20111272); 国家级大学生创新创业训练计划项目(201212121053); 

详细信息
  • 中图分类号: R575.2

Research progress in role of RhoA in onset and development of hepatic fibrosis

Research funding: 

 

  • 摘要:

    肝纤维化发生的关键在于肝星状细胞(HSC)转化为成纤维母细胞及活化后细胞外基质(ECM)的异常表达。回顾了Rho/ROCK信号通路在HSC的激活中的重要作用。总结了RhoA,作为Rho/ROCK信号通路上小G蛋白家庭成员之一,且作为一种重要的调节肌动蛋白细胞骨架和细胞形态异质性的细胞因子,参与肝纤维化的进程。指出RhoA在肝脏纤维化发生发展过程中起着重要的调控作用,归纳了RhoA通过调节肌动蛋白应力纤维的装配,并通过级联放大效应影响细胞基质的合成和收缩,最终影响肝纤维化的进展。就RhoA在肝纤维化过程中的机制以及RhoA作为潜在的治疗靶点作一综述。

     

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  • 收稿日期:  2012-12-24
  • 出版日期:  2013-08-20
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