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Clinical studies of stem cell transplantation to treat liver cirrhosis
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摘要:
<正>肝硬化是消化系统最常见的一种慢性疾病,是由病毒(HBV、HCV)、酒精等一种或多种原因引起的肝细胞广泛变性、坏死,肝脏弥漫性纤维化病变,进而形成再生结节和假小叶,导致正常肝小叶结构破坏,进一步发展为肝硬化,从而出现腹水、消化道出血、肝性脑病等一系列严重并发症,危及患者生命。目前,我国肝病患者大约7000万人,每年约有100多万人发展为肝硬化,数十万人死于肝硬化。原位肝移植是治疗肝硬化患者最理想的治疗选择,但因供体紧缺、免疫排斥、费用高等原因,导致临床应用十分有限,很难成为常规的治疗手段。随
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[1]Zimmermann A.Liver regeneration:the emergence of newpathways[J].Med Sci Monit, 2002, 8 (3) :RA53-63. [2]单云峰, 周伟平, 杨文, 等.大鼠肝卵圆细胞的分离培养和体外分化研究[J].中华实验外科杂志, 2005, 22 (8) :925-927. [3]Fujikawa T, Hirose T, Fujii H, et al.Purification of adult he-patic pro-genitor cells using green fluorescence protein (GFP) -transgenic mice and fluorescence-activated cellsorting[J].J Hepatol, 2003, 39 (2) :162-170. [4]Dan YY, Yeoh GC.Liver stem cells:a scientific and clinicalper-spective[J].J Gastroenterol Hepatol, 2008, 23 (5) :687-698. [5]Burt RK, Loh Y, Pearce W, et al.Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant dis-eases[J].JAMA, 2008, 299 (8) :925-936. [6]Dominici M, Le Blanc K, Mueller I, et al.Minimal criteria fordefining multipotent mesenchymal stromal cells.The interna-tional society for cellular therapy position statement[J].Cy-totherapy, 2006, 8 (4) :315-317. [7]Srivastava D, Ivey KN.Potential of stem-cell-based therapiesfor heart disease[J].Nature, 2006, 441 (7097) :1097-1099. [8]Cantz T, Manns MP, Ott M.Stem cells in liver regenerationand therapy[J].Cell Tissue Res, 2008, 331 (1) :271-282. [9]Aurich I, Mueller LP, Aurich H, et al.Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers[J].Gut, 2007, 56 (3) :405-415. [10]Chivu M, Dima SO, Stancu CI, et al.In vitro hepatic differ-entiation of human bone marrowmesenchymal stem cells un-der differential exposure to liver specific factors[J].Transl Res, 2009, 154 (3) :122-132. [11]Saulnier N, Campli CD, Zocco MA, et al.From stem cell to solid organ.Bone marrow, peripheral blood or umbilical cord blood as favorable source?[J].Eur Rev Med Pharmacol Sci, 2005, 9 (6) :315-324. [12]Pai M, Zacharoulis D, Milicevic MN, et al.Autologous infu-sion of expanded mobilized adult bone marrow-derived CD34+cells into patients with alcoholic liver cirrhosis[J].Am J Gastroenterol, 2008, 103 (8) :1952-1958. [13]Yan L, HanY, Wang J, et al.Peripheral blood monocytes from patients with HBV related decompensated liver cirrhosis can differentiate into functional hepatocytes[J].Am J He-matol, 2007, 82 (11) :949-954. [14]Han Y, Yan L, Han G, et al.Controlled trials in hepatitis B vi-rus-related decompensate liver cirrhosis:peripheral blood monocyte transplant versus granuiocyte-colony-stimula-ting factor mobilization therapy[J].Cytotherapy, 2008, 10 (4) :390-396. [15] 郭晓钟, 王迪, 邵晓冬, 等.自体骨髓干细胞移植治疗失代偿期肝硬化[J].中华消化杂志, 2009, 29 (7) :433-436. [16]黄茂涛, 季代金, 冯早明, 等.经肝动脉自体骨髓干细胞移植治疗失代偿期肝硬化[J].实用医学杂志, 2010, 26 (17) :3166-3168. [17]曹葆强, 林继宗, 钟跃思, 等.自体骨髓细胞经门静脉移植治疗肝硬化与肝功能不全的临床研究[J].中华普通外科杂志, 2007, 22 (5) :386-389. [18]Xu YQ, Liu ZC.Therapeutic potential of adult bone marrow stem cells in liver disease and delivery approaches[J].Stem Cell Rev, 2008, 4 (2) :101-112. [19]Gordon MY, Levicar N, Pai M, et al.Characterization and clini-cal application of human CD34+stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulation fac-tor[J].Stem Cells, 2006, 24 (7) :1822-1830. [20] Terai S, Ishikawa T, Omori K, et al.Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy[J].Stem Cells, 2006, 24 (10) :2292-2298. [21]Salama H, Zekri AR, Zern M, et al.Autologous hematopoi-etic stem cell transplantation in48patients with end-stage chronic liver diseases[J].Cell Transplant, 2010, 19 (11) :1475-1486. [22]Khan AA, Parveen N, Mahaboob VS, et al.Safety and efficacy of autologous bone marrow stem cell transplantation through hepatic artery for the treatment of chronic liver failure:a preliminary study[J].Transplant Proc, 2008, 40 (4) :1140-1144. [23]Lyra AC, Soares MB, da Silva LF, et al.Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease:a pilot randomized controlled study[J].Eur J Gastroenterol Hepatol, 2010, 22 (1) :33-42. [24]Stutchfield BM, Forbes SJ, Wigmore SJ.Prospects for stem cell transplantation in the treatment of hepatic disease[J].Liver Transpl, 2010, 16 (7) :827-836. [25]姚鹏, 胡大荣, 王帅, 等.自体骨髓干细胞移植治疗慢性肝衰竭研究[J].肝脏, 2005, 10 (3) :171-173. [26]金波, 孟繁平, 冯宇, 等.肝动脉超选灌注自体骨髓干细胞治疗失代偿期乙型肝炎肝硬化的临床研究[J].传染病信息, 2011, 24 (3) :143-146. [27]卫敏, 高文军, 高齐明, 等.骨髓干细胞原位移植治疗失代偿期乙型肝炎肝硬化[J].贵阳医学院学报, 2011, 36 (3) :266-268. [28]王方, 张小岗, 张静, 等.自体骨髓干细胞治疗失代偿期肝硬化患者50例疗效观察[J].实用肝脏病杂志, 2010, 13 (4) :272-274. [29]周炳喜, 郭俊贤, 韩双印, 等.脐带间充质干细胞移植治疗终末期肝硬化的疗效及安全性[J].中国组织工程研究与临床康复, 2011, 15 (32) :5987-5990. [30]陈海鸥, 胡小宣, 刘洪娟, 等.脐血干细胞移植治疗肝硬化的疗效观察[J].肝脏, 2010, 15 (2) :81-83. [31]张月凡, 李楠, 翟俊山, 等.人脐带间充质干细胞治疗失代偿期肝硬化的近期效果[J].中国组织工程研究, 2012, 16 (14) :2585-2588. [32]乔飞, 张馨, 盛云峰, 等.脐带血干细胞治疗肝硬化失代偿期疗效观察[J].中国肝脏病杂志 (电子版) , 2011, 3 (2) :10-13. [33]翁敬飚, 阮海兰, 韦玲, 等.人脐带干细胞外周静脉移植治疗失代偿期肝硬化的临床疗效[J].武汉大学学报 (医学版) , 2010, 31 (4) :541-543. [34]杨华强, 王云甫, 杜玲, 等.脐血干细胞移植治疗失代偿期肝硬化的临床疗效[J].现代生物医学进展, 2010, 10 (23) :4497-4499. -
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