40岁以上HBeAg阳性和阴性慢性乙型肝炎病毒感染者的临床特点比较

李春霞; 徐光华; 潘怀强; 刘娜

40岁以上HBeAg阳性和阴性慢性乙型肝炎病毒感染者的临床特点比较

延安大学附属医院感染病科

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中图分类号: R512.62
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出版历程
- 出版日期: 2012-06-20

Clinical differences between HBeAg-positive and-negative chronic hepatitis B patients over 40-years-old

摘要

摘要: 目的探讨40岁以上HBeAg阳性和HBeAg阴性慢性HBV感染者的临床特点。方法收集40岁以上慢性HBV感染者共186例,其中HBeAg阳性组93例,HBeAg阴性组93例。结果 40岁以上HBeAg阳性慢性HBV感染者男性为多(76.34%),并且多有乙型肝炎家族聚集现象(78.49%);40岁以上HBeAg阳性慢性HBV感染者的HBV DNA水平与ALT水平均高于HBeAg阴性慢性HBV感染者;40岁以上乙型肝炎肝硬化患者中,HBeAg阳性者占少数;40岁以上乙型肝炎肝硬化失代偿期患者中,HBeAg阳性者多合并腹水形成,而HBeAg阴性者既可见腹水形成,又可见上消化道出血。结论 40岁以上HBeAg阳性慢性HBV感染者多见于男性,多具有家族聚集现象,HBeAg阳性肝硬化患者所占比率较低,但HBV DNA水平较高,肝脏的炎症活动明显,病情进展可能较快。
- 肝炎e抗原,乙型 /
- 肝炎,乙型,慢性 /
- 肝硬化
Abstract: Objective To determine the differential clinical characteristics between hepatitis B e antigen (HBeAg) -positive and-negative patients with chronic hepatitis B virus (HBV) infection who are over 40-years-old.Methods A total of 186 patients with chronic HBV and over 40-years-old were analyzed, including 93 HBeAg-positive patients and 93 HBeAg-negative patients.Results In the HBeAg-positive group, 76.34% were male and 78.49% had a family history of HBV infection.The HBeAg-positive group had higher levels of HBV DNA and ALT, and a higher proportion of cirrhosis cases, than the HBeAg-negative group.Ascites were detected in patients from both groups diagnosed with decompensated cirrhosis.Upper gastrointestinal bleeding was more frequent in the HBeAg-negative group.Conclusion In our study of chronic HBV patients over 40-years-old, HBeAg-positivity was more frequent in males with a family history of HBV.HBeAg-negativity was more frequently associated with liver cirrhosis.It is possible that progression of chronic HBV may be related to high levels of HBV DNA and persistent liver inflammation.
- hepatitis B e antigens /
- hepatitis B /
- chronic

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参考文献(9)

[1]Liaw YF.Natural history of chronic hepatitis B virus infection andlong-term outcome under treatment[J].Liver International, 2009, 29 (s1) :100-107.

[2]贾继东.乙型肝炎e抗原阴性慢性乙型肝炎的治疗[J].中华肝脏病杂志, 2005;13 (7) :539.

[3]赵巍, 张汉荣, 刘新钰, 等.乙型肝炎病毒C基因启动子和前C基因变异对HBeAg表达及病情的影响[J].中国生化药物杂志, 2004, 25 (3) :165-166.

[4]任慧琼, 傅青春.乙型肝炎的自然史和预后[J].肝脏, 2003, 8 (3) :36-37.

[5]陈成伟.血清乙型肝炎病毒载量与肝细胞癌发生的关系[J].中华内科杂志, 2005, 44 (9) :715-716.

[6]王豪.HBeAg阴性慢性乙型肝炎[J].肝脏, 2004, 9 (S1) :24-28.

[7]Tong SP, Kim KH, Chante C, et al.Hepatitis B virus e antigen va-riants[J].Int J Med Sci, 2005, 2 (1) :2-7.

[8]杨创国, 于乐成, 陈金军, 等.1686例慢性乙型肝炎中HBeAg阴性与阳性患者临床和病毒学特点比较分析[J].中华内科杂志, 2005, 44 (9) :648-651.

[9]Peng J, Luo K, Zhu Y, et al.Clinical and histological characteristicsof chronic hepatitis B with negative hepatitis B e-antigen[J].ChinMed J (Engl) , 2003, 116 (9) :1312-1317.

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