酒精性肝病合并肝炎病毒感染的临床特点分析

刘祥英; 张一

酒精性肝病合并肝炎病毒感染的临床特点分析

刘祥英,
张一

南昌大学第一附属医院感染科

详细信息

中图分类号: R575;R575.1
计量
- 文章访问数: 3306
- HTML全文浏览量: 31
- PDF下载量: 686
- 被引次数: 0
出版历程
- 出版日期: 2012-04-20

Analysis of clinical characteristics of alcoholic liver disease cases infected with hepatitis viruses

摘要

摘要: 目的探讨酒精性肝病合并肝炎病毒感染的临床特点,评价酒精性肝病与肝炎病毒感染的关系。方法选择我院2004年1月至2011年5月收治经确诊的271例酒精性肝病患者,对其临床资料及实验室结果进行回顾性分析。结果 271例酒精性肝病中118例(43.5%)肝炎病毒标志物阳性,其中乙型肝炎病毒标志物阳性的101例(37.3%),丙型肝炎病毒标志物阳性的2例(0.7%),戊型肝炎病毒标志物阳性的14例(5.2%),甲型肝炎病毒标志物阳性的1例(0.3%),无肝炎病毒感染的153例(56.5%)。肝炎病毒感染阳性组上消化道出血、肝性脑病百分率比较差异有统计学意义(P<0.05)。两组血清肝功能均有不同程度的异常,且阳性组ALT、AST、TBil、GGT明显高于阴性组,差异有统计学意义(P<0.05)。结论酒精与肝炎病毒对肝脏损伤有协同作用,酒精性肝病合并肝炎病毒感染加重肝脏的损伤。
- 肝疾病,酒精性 /
- 肝炎病毒
Abstract: Objective To explore the clinical characteristics of ALD cases infected with hepatitis viruses and to evaluate the relationship of ALD with hepatitis virus infection.Methods 271 ALD cases from January 2004 to May 2011 were selected.The clinical manifestations and laboratory test results were retrospectively analyzed.Results 118 of 271 ALD cases (43.5%) were infected with hepatitis virus, among which, HBV, HCV, HEV and HAV infection was found in 101 (37.3%) , 2 (0.7%) , 14 (5.2%) and 1 (0.3%) respectively.The significant deviation was shown in incidence rate of upper gastrointestinal hemorrhage and hepatic encephalopathy between hepatitis virus infected group and non-infected group (P<0.05) .The two groups′ serum liver function were at different degree of abnormality, with ALT, AST, TBil, GGT of positive group significantly higher than the negative groups, showing significant differences (P<0.05) .Conclusion Alcoholand hepatitis viruses play a role of synergistic action in causing damage to liver.The liver function was more serious in ALD cases infected with hepatitis viruses.
- liver diseases /
- alcoholic

HTML全文

参考文献(12)

[1] 中华医学会.酒精性肝病治疗指南 (2010年修订版) [J].中华肝脏病杂志, 2010, 3 (18) :167-170.

[2]Bialek SR, Redd JT, Lynch A, et al.Chronic liver disease a-mong two American Indian patient populations in the south-western United States, 2000-2003[J].J Clin Gastroen-terol, 2008, 42 (7) :949-954.

[3]孟晓丹, 向国卿, 贺小虎, 等.肝硬化病因及临床特点分析178例[J].世界华人消化杂志, 2008, 16 (17) :1880-1884.

[4]刘阳, 刘德东, 迟宝荣.酒精性肝硬化合并肝炎病毒感染的临床特点[J].吉林医学, 2005, 26 (2) :158-159.

[5]张鸣, 沈薇.824例肝硬化病因及相关分析[J].重庆医学, 2006, 35 (5) :438-439, 441.

[6]Saito H, Masuda T, Tashita A, et al.Effect of ethanol onmouse hepatitis virus-induced cytotoxicity[J].J Gastroen-terol, 1996, 31 (5) :679-683.

[7]陈建, 赵卫东, 王敏, 等.乙型肝炎病毒对酒精性肝病易感性的影响[J].中华内科杂志, 2005, 44 (8) :611-612.

[8]陈建, 许建民, 王敏, 等.基因芯片检测乙醇对慢性乙型肝炎患者乙肝病毒多位点基因突变的研究[J].中国病理生理杂志, 2008, 24 (3) :573-576.

[9]Kim WH, Hong F, Jaruga B, et al.Hepatitis B virus X pro-tein sensitizes primary mouse hepatocytes to ethanol-andTNF-alpha-induced apoptosis by a caspase-3-depend-ent mechanism[J].Cell Mol Immunol, 2005, 2 (1) :40-48.

[10]虞朝辉, 陈卫星, 陈韶华, 等.嗜酒合并乙型肝炎病毒感染与转化生长因子B1表达水平的关系[J].中华消化杂志, 2004, 24 (3) :178-179.

[11]赵卫东, 朱建友, 陈建, 等.酒精对乙型肝炎病毒复制和基因表达的影响[J].临床医学, 2007, 27 (4) :75-77.

[12]Larkin J, Clayton MM, Liu J, et al.Chronic ethanol con-sumption stimulates hepatitis B virus gene expression andreplication in transgenic mice[J].Hepatology, 2001, 34 (4Pt 1) :792-797.

施引文献

资源附件(0)

访问统计