组蛋白去乙酰化酶1及基质金属蛋白酶-2在肝细胞癌组织中的表达及意义

王迎春; 刘炎芳; 朱瑞萍; 宋欣新; 李小欢

组蛋白去乙酰化酶1及基质金属蛋白酶-2在肝细胞癌组织中的表达及意义

1. 大连大学附属中山医院消化内科
2. 大连大学附属中山医院病理科
3. 大连大学附属中山医院中心实验室

基金项目:

大连市医学卫生科学研究计划项目(2011178)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2012-04-20

Expression of histone deacetylase 1 and matrix metalloproteinase-2 in hepatocellular carcinoma and its significance

Research funding:

摘要

摘要: 目的探讨组蛋白去乙酰化酶1（HDAC1）及基质金属蛋白酶-2（MMP-2）在肝细胞癌（HCC）患者肝组织中的表达及其临床意义。方法采用免疫组织化学方法检测42例HCC和相应的癌旁组织中HDAC1及MMP-2蛋白的表达,并分析其与临床病理参数的关系。结果 HCC组织中,HDAC1及MMP-2蛋白的表达明显高于癌旁组织（P<0.01,P<0.05）;HDAC1蛋白的表达与患者性别、年龄、肿瘤大小、AFP浓度、肿瘤分化程度、脉管癌栓无关联（P>0.05）,与肿瘤TNM分期相关联（P<0.05）;MMP-2蛋白的表达与患者性别、年龄、肿瘤大小、AFP浓度、肿瘤分化程度无关联（P>0.05）,与脉管癌栓、肿瘤TNM分期相关联（P<0.05,P<0.01）;HCC组织中,HDAC1及MMP-2蛋白的表达呈正相关（P<0.01）。结论 HDAC1及MMP-2在HCC患者肝组织中表达有一定的肿瘤特异性,二者的高表达提示HCC已属晚期。
- 癌,肝细胞 /
- 组蛋白去乙酰化酶1 /
- 基质金属蛋白酶类
Abstract: Objective To study the expression of HDAC1 and MMP-2 in liver tissues of patients with hepatocellular carcinoma (HCC) and its significance.Methods Immunohistochemical analysis was used to detect the expression of HDAC1 and MMP-2 in 42 cases of HCC.Results The positive rate of HDAC1 and MMP-2 was significantly higher in HCC than that in para-cancerous tissues (P<0.01, P<0.05) , the expression of HDAC1 was not associated with patients′ gender, age, tumor size, alpha fetoprotein, histological grade and vessel embolus (P>0.05) , but was significantly associated with patients′ TNM stage (P<0.05) , the expression of MMP-2 was not associated with patient gender, age, tumor size, alpha fetoprotein, histological grade (P>0.05) , but was significantly associated with patient vessel embolus and TNM staging (P<0.05, P<0.01) , HDAC1 was positively correlated with MMP-2 expression in HCC.Conclusion In HCC tissues, increased HDAC1 and MMP-2 expression may associate to the hepatocarcinogenesis, and may indicate the status of advanced TNM stage.
- carcinoma /
- hepatocellular /
- histonedeacetylases1

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参考文献(10)

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