中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

21世纪肝癌临床研究面临的挑战

汤钊猷

引用本文:
Citation:

21世纪肝癌临床研究面临的挑战

详细信息
  • 中图分类号: R735.7

21st century:challenges facing the clinical research of liver cancer

  • 摘要: <正>20世纪,建立在病理学基础上以消灭肿瘤为目标的战略,导致肝癌临床的重大进步,但距离攻克还有很大距离,为此21世纪仍面临重大挑战。1消灭肿瘤战略功不可没20世纪以消灭肿瘤为目标的疗法(手术、放化疗、局部治疗等)取得了有史以来最大的进步;早诊早治又进一步大幅度提高了疗效。美国肝癌人群的统计,

     

  • [1]Jemal A, Bray F, Center MM, et al.Global cancer statistics[J].CA Cancer J Clin, 2011, 61 (2) :69-90.
    [2]Liu L, Zhu XD, Wang WQ, et al.Activation of beta-cateninby hypoxia in hepatocellular carcinoma contributes to en-hanced metastatic potential and poor prognosis[J].ClinCancer Res, 2010, 16 (10) :2740-2750.
    [3]Huang XY, Huang ZL, Wang L, et al.Herbal compound"Songyou Yin"reinforced the ability of interferon-alfa to in-hibit the enhanced metastatic potential induced by palliativeresection of hepatocellular carcinoma in nude mice[J].BMCCancer, 2010, 10:580.
    [4]Ellis LM, Reardon DA.Is there really a yin and yang to VEGF-targeted therapies[J].Lancet Oncol, 2010, 11 (9) :809-811.
    [5]Ye QH, Qin LX, Forgues M, et al.Predicting hepatitis B vi-rus-positive metastatic hepatocellular carcinomas usinggene expression profiling and supervised machine learning[J].Nat Med, 2003, 9 (4) :416-423.
    [6]Shen YC, Hsu C, Chen LT, et al.Adjuvant interferon therapyafter curative therapy for hepatocellular carcinoma (HCC) :ameta-regression approach[J].J Hepatol, 2010, 52 (6) :889-894.
    [7]Zhang XW, Yan XJ, Zhou ZR, et al.Arsenic trioxide controlsthe fate of the PML-RARalpha oncoprotein by directly bind-ing PML[J].Science, 2010, 328 (5975) :240-243.
    [8]Grivennikov SI, Greten FR, Karin M.Immunity, inflamma-tion, and cancer[J].Cell, 2010, 140 (6) :883-899.
    [9]Dinarello CA.Anti-inflammatory agents:present and future[J].Cell, 2010, 140 (6) :935-950.
    [10]Jacobs EJ.Will an aspirin a day help keep fatal cancer away?[J].Lancet, 2011, 377 (9759) :3-4.
    [11]Zhang W, Zhu XD, Sun HC, et al.Depletion of tumor-associ-ated macrophages enhances the effect of sorafenib in metastat-ic liver cancer models by antimetastatic and antiangiogeniceffects[J].Clin Cancer Res, 2010, 16 (13) :3420-3430.
    [12]Hart GW, Copeland RJ.Glycomics hits the big time[J].Cell, 2010, 143 (5) :672-676.
    [13]Thaker PH, Han LY, Kamat AA, et al.Chronic stress pro-motes tumor growth and angiogenesis in a mouse model ofovarian carcinoma[J].Nat Med, 2006, 12 (8) :939-944.
    [14]Ondicova K, Mravec B.Role of nervous system in cancer aetio-pathogenesis[J].Lancet Oncol, 2010, 11 (6) :596-601.
    [15]Xiong W, Ren ZG, Qiu SJ, et al.Residual hepatocellular car-cinoma after oxaliplatin treatment has increased metastaticpotential in a nude mouse model and is attenuated by Songy-ou Yin[J].BMC Cancer, 2010, 10:219.
  • 加载中
计量
  • 文章访问数:  2164
  • HTML全文浏览量:  11
  • PDF下载量:  783
  • 被引次数: 0
出版历程
  • 出版日期:  2012-04-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回