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A clinical observation on metadoxine combined with tiopronin in the treatment of patients with alcoholic liver disease
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摘要: 目的观察美他多辛联合硫普罗宁治疗酒精性肝病的疗效。方法 60例酒精性肝病住院患者随机分为治疗组和对照组各30例,两组一般治疗相同,对照组用硫普罗宁,治疗组在对照组基础上加用美他多辛片。治疗前后分别查TBil、ALT、AST、GGT、A/G、TC、TG等生化指标,并记录临床症状和体征变化。结果 4周后,治疗组总有效率96.67%,明显高于对照组的76.67%;治疗组治疗后的TBil、ALT、AST、GGT、A/G、TC、TG水平明显低于对照组,差异均有统计学意义(P<0.01)。两组在治疗期间均无明显不良反应。结论美他多辛和硫普罗宁联用疗效优于单用硫普罗宁。Abstract: Objective To evaluate the efficiency of metadoxine combined with tiopronin in the treatment of patients with alcoholic liver disease. Methods 60 cases of hospitalized patients with alcoholic liver disease were randomly divided into treatment group and control group with 30 cases in each group. The two groups received the same general treatment, and the control group was treated with tiopronin while the treatment group was added with metadoxine tablets based on the treatment of the control group.The TBil, ALT, AST, GGT, A/G, TC, TG and other biochemical indices were detected before and after treatment respectively, and the clinical symptoms and signs were observed. Results After 4 weeks, the total treatment efficiency was 96.67% in treatment group, which was significantly higher than that in control group 76.67%; after treatment the TBil, ALT, AST, GGT, A/G, TC, TG levels were significantly lower in treatment group than those in the control group, the difference was statistically significant (P<0.01) . There was no obvious adverse reaction in both the two groups. Conclusion Metadoxine and tiopronin combined treatment shows better effect than the single treatment with tiopronin.
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Key words:
- liver disease /
- alcoholic /
- tiopronin
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