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FibroScan在乙型肝炎诊断中的应用价值

苟艳子 杨苏亚 张方信 康生朝 梁振斌 陈嘉屿 汪咏 王维 潘蕾 刘博 白雪帆

引用本文:
Citation:

FibroScan在乙型肝炎诊断中的应用价值

基金项目: 

国家十一五课题基金(2008zx10002-004); 

详细信息
  • 中图分类号: R512.62

The application of FibroScan in the diagnosis of patients with hepatitis B virus infection

Research funding: 

 

  • 摘要: 目的研究Fibroscan在乙型肝炎病毒感染患者中的应用价值;评估肝纤维化测量值的变化及临床意义。方法本研究是一个随机、开放的临床研究。2009年7月至2010年2月的74例乙型肝炎感染患者均接受至少两次Fibroscan检查,血清中ALT、AST及TBil的检查采用自动分析仪检查,所有74例患者(22例慢性乙型肝炎,32例代偿性肝硬化,20例失代偿性肝硬化)接受替比夫定治疗。结果 22例慢性乙型肝炎患者FibroScan值治疗6个月后降低,在治疗前后两组FibroScan值差异有统计学意义;74例乙型肝炎病毒感染患者肝功能治疗6个月后降低,差异具有统计学意义。74例乙型肝炎病毒感染患者中,HA与LSM呈显著正相关性(r=0.517,P=0.048)。结论慢性乙型肝炎患者肝硬度经过治疗可以降低。在替比夫定治疗的慢性乙型肝炎患者中肝硬度值的变化是敏感的。FibroScan将是一个在临床新药实验中评价治疗效果的有用工具。

     

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