150例儿童非嗜肝病毒感染相关性肝炎临床特征分析

贺宝平; 孙梅

150例儿童非嗜肝病毒感染相关性肝炎临床特征分析

贺宝平,
孙梅

中国医科大学附属盛京医院小儿消化内科

详细信息

中图分类号: R725.1
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出版历程
- 出版日期: 2011-07-20

Analysis of clinical characteristics of 150 cases of pediatric hepatitis caused by nonhepatotropic pathogen

He BaoPing,
Sun Mei

摘要

摘要: 目的探讨儿童非嗜肝病毒感染相关性肝炎的临床特征。方法回顾性分析2009年1月～2010年9月期间住院治疗的150例诊断为非嗜肝病毒感染相关性肝炎病例的临床特征。结果 150例患儿中,男81例,女69例。引起儿童非嗜肝病毒感染相关性肝炎的病原体以肺炎支原体和EB病毒最常见,分别为69例(46.0%)和59例(39.3%),治疗后ALT、AST明显下降。结论儿童非嗜肝病毒感染相关性肝炎的临床表现是非特异性的,进行综合性治疗是治愈本病的关键。
- 肝炎 /
- 非嗜肝病毒感染
Abstract: Objective To study the clinical characteristics of pediatric hepatitis caused by nonhepatotropic pathogen.Methods Retrospective analysis of the clinical characteristics of 150 cases diagnosed with non-hepatotropic pathogen related hepatitis in pediatric gastroenterology department, Shengjing hospital during Jan, 2009 to Sept, 2010 were studied.Results There were 81 males and 69 females in the 150 cases.Mycoplasma pneumoniae and EB virus were the main causes of the non-hepatotropic pathogen related hepatitis, with 69 cases (46%) and 59 cases (39.33%) respectively.Compared with pre-treatment, there were significant reduction in the level of ALT and AST (P<0.05) after treatment.Conclusion The results show that the clinical manifestations of non-hepatotropic pathogen related hepatitis are nonspecific.ALT and AST can be used to confirm the diagnosis.Early diagnosis and treatment are the key points to improve the prognosis.
- hepatitis /
- non-hepatotropic virus infection

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参考文献(17)

[1]蔡莹, 周晓霞, 方静, 等.86例小儿非嗜肝病毒感染所致肝功能损害的临床分析[J].中国当代儿科杂志, 2009, 11 (2) :148-150.

[2]Principi N, Esposito S.Mycoplasma pneumonia and Chlamydiapneumonia cause lower respiratory tract disease in paediatricpatients[J].Curr Opin Infect Dis, 2002, 15 (4) :295.

[3]张晓波, 王立波, 张灵恩, 等.儿童肺炎支原体感染肺外脏器受累56例临床分析[J].临床儿科杂志, 2003, 21 (6) :344-346.

[4]汤文红, 曹秀章.小儿呼吸道肺炎支原体感染发病趋势及临床分析[J].临床儿科杂志, 2005, 23 (8) :562-563.

[5]宋顺琪, 吴茜, 倪林仙, 等.小儿肺炎支原体、嗜肺军团菌并肝损伤15例分析[J].中国实用医药, 2010, 5 (22) :183.

[6]Feigin RD, Cherry DJ.Testbook of pediatric infectious diseases[M].5th ed.Pennsylvania:W.B.Saunders, 2004:2516-2547.

[7]Hammerschlag M.Mycoplasma pneumoniae infections[J].CurrOpin Infect Dis, 2001, 14 (2) :181-186.

[8]Daxboeck F, Gattringer R, Mustafa S, et al.Elevated serum alanineaminotransferase (ALT) levels in patients with serologically verifiedMycoplasma pneumoniae pneumonia[J].Clin Microbiol Infect, 2005, 11 (6) :507-510.

[9]Smets F, Latinne D, Bazin H, et al.Ratio between Epstein-Barr viralload and anti-Epstein-Barr virus specific T cell response as apredictive marker of posttransplant lymphoproliferative disease[J].Transplantation, 2002, 73 (10) :1603-1610.

[10]Kimura H, Nagasaka T, Hoshino Y, et al.Severe hepatitis causedby Epstein-Barr virus without infection of hepatocytes[J].HumPathol, 2001, 32 (7) :757-762.

[11]孙雪荣, 陈佳红, 于春, 等.EB病毒感染与婴儿肝炎综合征的临床研究[J].中国全科医学, 2008, 11 (8) :652-653, 657.

[12]Macsween KF, Crawford DH.Epstein-Barr virus recentadvances[J].Lancet Infect Dis, 2003, 3 (3) :131-140.

[13]Shibuya A, Tsuchihashi T, Watanabe M, et al.Severe chronic activeEpstein-Barr virus infection associated with multiple necroticlesions in the liver[J].Hepatol Res, 2003, 25 (4) :447-454.

[14]Wang J, Atchison RW, Walpusk J, et al.Echo virus hepaticfailure in infancy:report of four cases with speculation on thepathogenesis[J].Pediatr Dev Pathol, 2001, 4 (5) :454-460.

[15]周智, 赖宁, 王明桃, 等.68例非嗜肝病毒所致肝炎患者病因学分析及其临床特点[J].中华肝脏病杂志, 2004, 12 (3) :130.

[16]白淑霞, 付宇, 李文芳, 等.EB病毒感染致严重肝损害死亡2例分析[J].中国误诊学杂志, 2010, 10 (1) :220-221.

[17]高建兴, 黄莹.慢性活动性EB病毒感染致肝硬化1例[J].现代中西医结合杂志, 2009, 18 (30) :3758-3759.

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