Abstract: Objective To study on the influence of combination therapy of matrine with adefovir dipivovir (ADV) on hepatic fibrosis level resulting from chronic hepatitis B.Methods Divide 116 patients with chronic hepatitis B into three groups at random.Group A:38 patients received matrine capsule (200mg po tid) ;Group B: 38 patients received 10 mg of ADV a day;group C: 40 patients received combine therapy of ADV and matrine.The course of treatment lasted for 48 weeks.During the treatment, liver function, HBV DNA in the serum, hepatic fibrosis level, internal diameter of portal vein trunk, splenic thickness and drug adverse reactions of patients in each group was checked.Results There was statistical difference of the ALT normalization between the patients in Group A and those in Group C (P<0.05) .After 36 weeks of treatment, the negativity rate of HBV DNA of the patients in group C was higher than those in group A and B (P<0.05) .After 24 weeks of treatment on patients in Group B and C and after 36 weeks in Group A, their PCⅢ, CⅣ, LN, HA levels in the serum declined dramatically compared with the ones prior to the treatment (P<0.05) ;at week 48, there was statistical differences between the PCⅢ, CⅣ, HA (except LN) levels in the serum of the patients in Group C and those in Group A (P<0.05) .At 24, 48 weeks, the spleen of the patients in Group C became smaller and existed statistical difference compared with the ones prior to the treatment (P<0.05) .Totally there were 5 patients in Group B and C appeared adverse drug reactions but all were tolerated.Conclusion Combination therapy of Marine with ADV was more effective than separate therapy of matrine or ADV, when treating for hepatic fibrosis.