瘦素及脂联素与非酒精性脂肪性肝病

孔银; 张岭漪

瘦素及脂联素与非酒精性脂肪性肝病

孔银,
张岭漪

兰州大学第二医院肝病科甘肃省消化肿瘤重点实验室

详细信息

中图分类号: R575.5
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出版历程
- 出版日期: 2011-04-20

The role of leptin and adiponectin in non-alcoholic fatty liver disease

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)作为代谢综合征在肝脏的表现,是一个多因素共同作用的结果,近年来已成为临床高发疾病之一。除了胰岛素抵抗(IR)在本病发生发展过程中起着重要作用外,脂联素(APN)、瘦素(LP)水平变化与胰岛素抵抗以及与NAFLD的关系受到关注。本文就脂联素(APN)、瘦素(LP)在NAFLD发病中的作用予以综述。
- 瘦素 /
- 脂联素 /
- 脂肪肝
Abstract: Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome.Currently it is one of the highest incidence of disease worldwide, it is considered that the pathogenesis of NAFLD to be a multifactorial process.Insulin resistance (IR) has been confirmed to be implicated in the pathogenesis and progression of NAFLD.Recent studies focused on the role of leptin and adiponectin in NAFLD.We summarized the recent findings concerning the role of leptin and adiponectin in NAFLD.
- leptin /
- adiponectin /
- fatty liver

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参考文献(20)

[1]de Alwis NM, Day CP.Non-alcoholic fatty liver disease:themist gradually clears[J].J Hepatol, 2008, 48 (Suppl 1) :104-112.

[2]Farrell GC, Chitturi S, Lau GK, et al.Guidelines for theassessment and management of non-alcoholic fatty liverdisease in the Asia-Pacific region:executive summary[J].Gastroenterol Hepatol, 2007, 22 (6) :775-777.

[3]Laubner K, Kieffer TJ, Lam NT, et al.Inhibition of preproi-nsulin gene expression by leptin induction of suppressor ofcytokine signaling 3 in pancreatic bete-cells[J].Diabetes, 2005, 54 (12) :3410-3417.

[4]Sachithanandan N, Fam BC, Fynch S, et al.Liver-specificsuppressor of cytokine signaling-3 deletion in mice enhanceshepatic insulin sensitivity and lipogenesis resulting in fatty liverand obesity[J].Hepatology, 2010, 50 (5) :1632-1642.

[5]Li YL, Yang M, Meng XD, et al.The relationship of leptinand adiponectin with insulin resistance in nonalcoholic fattyliver disease[J].Zhonghua Gan Zang Bing Za Zhi, 2010, 18 (6) :459-462.

[6]Antal M, Regoly MA.New approach in the interpretation ofadipose tissue[J].Orv Hetil, 2010, 151 (31) :1252-1260.

[7]Hui JM, Hodge A, Farrell GC, et al.Beyond insulin resistancein NASH:TNF-alpha or adiponectin?[J].Hepatology, 2004, 40 (1) :46-54.

[8]Lee YS, Cho YK, Pae JC, et al.The relationship betweenserum adiponectin level and serum alanine aminotransferaseelevation in Korean male with nonalcoholic fatty liverdisease[J].Korean J Hepatol, 2006, 12 (2) :221-229.

[9]Tomita K, Oike Y, Teratani T, et al.Hepatic AdipoR2signaling plays a protective role against progression ofnonalcoholic steatohepatitis in mice[J].Hepatology, 2008, 48 (2) :458-473.

[10]Yoneda M, Iwasaki T, Fujita K, et al.Hypoadiponectinemiaplays a crucial role in the development of nonalcoholicfatty liver disease in patients with type 2 diabetes mellitusindependent of visceral adipose tissue[J].Alcohol Clin ExpRes, 2007, 31 (Suppl1) :S15-21.

[11]Martin SS, Qasim A, Reilly MP.Leptin resistance:a possibleinterface of inflammation and metabolism in obesity-relatedcardiovascular disease[J].J Am Coll Cardiol, 2008, 52 (15) :1201-1210.

[12]Munzberg H, Bjornholm M, Bates SH, et al.Leptin receptoraction and mechonisms of leptin resistance[J].Cell Mol LifeSci, 2005, 62 (6) :642-652.

[13]Polyzos SA, Kountouras J, Zavos C, et al.The PotentialAdverse Role of Leptin Resistance in Nonalcoholic FattyLiver Disease:A Hypothesis Based on Critical Review ofLiterature[J].Clin Gastroenterol, 2010, 45 (1) :50-54.

[14]Canbakan B, Tahan V, Balci H, et al.Leptin in nonalcoholicfatty liver disease[J].Ann Hepatol, 2008, 7 (3) :249-254.

[15]Saxena NK, Titus MA, Ding X, et al.Leptin as a novelprofibro-genic cytokine in hepatic stellate cells:mitogenesisand inhibition of apoptosis mediated by extracellularregulated kinase (Erk) and Akt phosphorylation[J].FASEB J, 2004, 18 (13) :1612-1614.

[16]Wang J, Brymora J, George J.Roles of adipokines in liverinjury and fibrosis[J].Expert Rev Gastroenterol Hepatol, 2008, 2 (1) :47-57.

[17]Yoon D, Lee SH, Park HS, et al.Hypoadiponectinemia andinsulin resistance are associated with nonalcoholic fatty liverdisease[J].Korean Med Sci, 2005, 20 (3) :421-426.

[18]Aygun C, Senturk O, Hulagu S, et al.Serum levels ofhepatoprotective peptide adiponectin in non-alcoholicfatty liver disease[J].Eur J Gastroenterol Hepatol, 2006, 18 (2) :175-180.

[19]Tsatsanis C, Zacharioudaki V, Androulidaki A, et al.Adiponectin induces TNF-alpha and IL-6 in macrophagesand promotes tolerance to itself and other pro-inflammatorystimuli[J].Biochem Biophys Res Commun, 2005, 335 (4) :1254-1263.

[20]Hindle AK, Edwards C, Mendonsa A, et al.Adiponectin butnot leptin is involved in early hepatic disease in morbidlyobese patients[J].Surg Endosc, 2010, 24 (7) :1547-1551.

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