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Three dimensional conformation radiotherapy for 35 cases of unresectable massive primary liver cancer
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摘要: 目的观察三维适形照射对不能手术的原发性大肝癌治疗效果。方法收集1997年10月至2008年6月不能手术的原发性大肝癌35例。肿瘤直径8～12 cm。根据Child-Pugh肝功能分级,A级26例,B级9例。采用三维适形放疗,每次照射剂量4～5 Gy,每周3次,总剂量50～55 Gy。结果放疗后2～3个月CT复查,CR 17.1%,PR 65.7%,NC 11.4%。1、2、3年生存率分别为71.4%、42.9%、20.0%,30例复查AFP,21例明显下降,其中8例恢复至正常水平。结论三维适形放疗对原发性肝癌有肯定的治疗效果,特别是对不能手术的大肝癌是一种有效的局部治疗手段。Abstract: Objective To evaluate the effect of three dimensional conformation radiotherapy (3-DCRT) for unresectable primary massive liver cancer.Methods From October 1997 to June 2008 35 unresectable massive primary liver cancer patients were analyzed, the tumor size were 8-12cm, including Child-Pugh Grade A and B respectively.The patients received 3-DCRT with total dose of 50-55 Gy, at 4-5 Gy/f, 3f/w.Results The CR was 17.1%, PR was 65.7%, and NC was 11.4% which were detected with CT images in 2-3 month after radiotherapy.1, 2 and 3 year survival rates were 71.4 %, 42.9% and 20%, respectively.AFP value in 30 cases was followed up.It was decreased significantly in 21 cases and 8 cases among them showed normal value of AFP.Conclusion 3-DCRT is effective in the treatment of liver cancer;especially for unresectable massive primary liver cancer, it is an effective local treatment method.
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Key words:
- liver neoplasms /
- radiotherapy
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