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Expression of Plk1 and Survivin in hepatocellular carcinoma and its significance
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摘要: 目的探讨Plk1和凋亡抑制蛋白Survivin在HCC中表达情况,为临床诊断和治疗提供理论依据。方法采用免疫组化法检测100例肝细胞癌标本中Plk1、Survivin的表达。结果⑴肝细胞癌中,Survivin蛋白的表达明显高于癌旁正常组织(P<0.05),Survivin在肝细胞癌组织中的表达与患者性别、年龄、肿瘤分化程度、AFP表达及是否侵犯肝被膜均无关联(P>0.05)。与HBsAg表达有关联(P<0.05)。⑵肝细胞癌组织中,Plk1阳性表达明显高于癌旁正常组织(P<0.05);Plk1在肝细胞癌组织中的表达与患者性别、年龄、AFP表达、HBsAg表达及是否侵犯肝被膜均无关(P>0.05),与肿瘤分化程度相关(P<0.05)。⑶肝细胞癌组织中,Plk1与Survivin表达呈正相关(P<0.05)。结论 Plk1与Survivin的联合检测为肝细胞癌的诊断和治疗提供新的依据。
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关键词:
- 基因表达 /
- 丝裂原激活蛋白激酶类 /
- 微管相关蛋白质类 /
- 癌,肝细胞
Abstract: Objective Investigating expression of Plk1 and survivin in hepatocellular carcinoma.providing theory for diagnosis and therapy in clinic.Methods Immunohistochemical analysis was used to detect the expression of Plk1 and Survivin in 100 cases of hepatocellular carcinoma.Results ⑴The positive rate of survivin expression in HCC was significantly higher than that in normol liver tissues (P<0.05) .There was no correlation between the expression of Survivin with patient gender, age, tumor differentiation, AFP and whether the violations were not associated with the liver capsule. (P>0.05) There was correlation between the expression of Survivin with the expression of HBsAg (P<0.05) .⑵The positive rate of Plk1 expression in HCC was significantly higher than that in normol liver tissues (P<0.05) .There was no correlation between the expression of Plk1 with patient's gender, age, AFP, HBsAg and whether the violations were not associated with the liver capsule (P>0.05) .There was correlation between the expression of Survivin with the tumor differentiation (P<0.05) .⑶Plk1 was positively correlated with Survivin expression in hepatocellular carcinoma (P<0.05) .Conclusion Detection of the Survivin and Plk1 can supply certain evidence on prognosis and treatment of hepatocellular cancer.-
Key words:
- carcinoma /
- hepatocellular /
- gene expression /
- mitogen-activated protein kinases
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[1]张庆, 刘南植, 洪玮, 等.胃癌组织Plk1的表达及其意义[J].世界华人消化杂志, 2005, 13 (13) :1499-1502. [2]Li F.Role of survivin and its splice variants in tumorigenesis[J].Br J Cancer, 2005, 92 (2) :212-216. [3]Sumara I, Giménez-Abáin JF, Gerlich D, et al.Roles of polo-like kinase 1 in the assembly of functional mitotic spindles[J].Curr Biol, 2004, 14 (19) :1712-1722. [4]Sunkel CE, Glover DM.Polo, a mitotic mutant of Drosophiladisplaying abnormal spindle poles[J].J Cell Sci, 1988, 89 (Pt1) :25-38. [5]Takai N, Hamanaka R, Yoshimatsu J, et al.Polo-likekinases (Plks) and Cancer[J].Oncogene, 2005, 24 (2) :287-291. [6]Sp?nkuch-Schmitt B, Bereiter-Hahn J, Kaufmann M, etal.Effect of RNA silencing of polo-like kinase-1 (Plk1) onapoptosis and spindle formation in human cancer cells[J].Natl CancerInst, 2002, 94 (24) :1863-1877. [7]Chen XJ, Wu LM, Xu XB, et al.Expression and prognosticvalue of Polo-like kinase 1, E-cadherin in the patients withhepatocellular carcinoma[J].Zhonghua Wai ke Za Zhi, 2007, 45 (19) :1354-1358. [8]何自力, 钟德玝, 郑核, 等.原发性肝癌Plk1基因表达及其与预后的相关性[J].世界华人消化杂志, 2009, 17 (2) :146-150. -
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