上海市成人胆石症患病率及危险因素的流行病学调查

朱永湘; 范建高; 李锐; 李新建

上海市成人胆石症患病率及危险因素的流行病学调查

1. 上海交通大学医学院附属新华医院消化内科
2. 上海市疾病预防控制中心

详细信息

中图分类号: R575.62
计量
- 文章访问数: 233
- HTML全文浏览量: 20
- PDF下载量: 317
- 被引次数: 0
出版历程
- 出版日期: 2010-06-20

Prevalence of cholelithiasis and associated risk factors among adult population in Shanghai

摘要

摘要: 目的明确上海市成人胆石症的患病率及其危险因素。方法通过随机多级分层整群抽样对杨浦区和浦东新区各4个居委会15岁以上居民进行调查,内容涉及问卷咨询、体格检查、75g葡萄糖耐量试验、血脂检测、以及肝脏及胆道系统实时超声检查。结果 3173名15岁以上人群成为此次调查的研究对象,约占上海市人口2.26/10000。男性1217名,女性1956名。年龄15～88岁,平均(52.4±15.1)岁,男女间年龄差异无统计学意义。B超共检出胆石症339例(10.7%),经年龄和性别调整后,上海市成人胆石症患病率为7.5%。男性和女性的胆石症患病率均随年龄增长而增加。单因素分析显示,胆石症组年龄、体重指数、收缩压、舒张压、空腹及餐后2小时血糖、甘油三酯、低密度脂蛋白胆固醇(P<0.01)、总胆固醇(P<0.05)均显著高于非胆石症组,而高密度脂蛋白胆固醇则低于非胆石症组(P<0.01)。男性胆石症危险因素包括肥胖、高血压病、糖耐量异常/糖尿病以及脂肪肝(P<0.05);女性胆石症危险因素包括肥胖、中心性肥胖、高血压病、糖耐量异常/糖尿病、高胆固醇血症、高甘油三酯血症以及脂肪肝(P...
- 胆石 /
- 患病率 /
- 危险因素
Abstract: Objective To investigate the prevalence and major risk factors of cholelithiasis among adult residents in Shanghai.Methods A cross-sectional survey was performed among residents above 15 years of age in four communities of Yangpu District and Pudong New District using multiple-stage stratified cluster sampling.Data was collected from a total of 3173 residents using questionnaire.Physical examination, serum lipids, 75 gram oral glucose tolerance test and ultrasonographic examination of biliary system were undertaken.Data was analyzed using SPSS 15.0.Results Of the 3173 residents who participated on the study, 1217 were males and 1956 were females.The mean age of the participants was (52.4 ± 15.1) years and ranged from 15-88 years.Cholelithiasis was detected by ultrasound examination in 339 participants (10.7%) , the age-adjusted and sex-adjusted prevalence of cholelithiasis in Shanghai adult residents was 7.5%.The prevalence of cholelithiasis increased with age both in males and females.The age, body mass index, blood pressure, fasting and two hour serum glucose level, triglyceride, low-density lipoprotein cholesterol (P < 0.01) and total cholesterol (P < 0.05) in the cholelithiasis group were significantly higher than the non cholelithiasis group.The high-density lipoprotein level was lower in the cholelithiasis group (P < 0.01) .Obesity, hypertension, impaired glucose tolerance/diabetes mellitus and fatty liver were positively associated with the risk of gallstone disease in both men and women.Central obesity, hypertriglyceridemia and hypercholesterolemia were risk factors for gallstone disease only in women (P < 0.05) .The prevalence of cholelithiasis was positively correlated with three risk factors such as age, systolic pressure and fatty liver.Conclusion There is a high prevalence of cholelithiasis among adult residents in Shanghai.Age, obesity, hypertension, impaired glucose tolerance/diabetes mellitus and fatty liver are closely associated with cholelithiasis.
- gaustones /
- prevalence /
- risk factors

HTML全文

参考文献(13)

[1]罗政仁, 张国华, 陈劲勇, 等.邵阳市区成人胆石症患病率及其危险因素流行病学调查[J].现代消化及介入诊疗, 2007, 12 (1) ∶4-8.

[2]Chen CH, Huang MH, Yang JC, et al.Prevalence and risk factors of gallstone disease in an adult population of Taiwan:an epidemiological survey[J].J Gastroenterol Hepatol, 2006, 21 (11) ∶17371743.

[3]Einarsson K, Nilsell K, Leijd B, et al.Influence of age on secretion of cholesterol and synthesis of bile acids by the liver[J].N Engl J Med, 1985, 313 (5) ∶277-282.

[4]Kucio C, Besser P, Jonderko K.Gallbladder motor function in obese versus lean females[J].Eur J Clin Nutr, 1998, 42 (2) ∶121-124.

[5]Maurer KR, Everhart JE, Knowler WC, et al.Risk factors for gallstone disease in the Hispanic populations of the United States[J].Am J Epidemiol, 1990, 131 (5) ∶836-844.

[6]Tsai CJ, Leitzmann MF, Willett WC, et al.Macronutrients and in-sulin resistance in cholesterol gallstone disease[J].Am J Gastroenterol, 2008, 103 (11) ∶2932-2939.

[7]Chapman BA, Chapman TM, Frampton CM, et al.Gallbladder volume:comparison of diabetics and controls[J].Dig Dis Sci, 1998, 43 (2) ∶344-348.

[8]Jonkers IJ, Smelt AH, Ledeboer M, et al.Gallbladder dysmotility:a risk factor for gallstone formation in hypertriglyceridaemia and reversal on triglyceride lowering therapy by bezafibrate and fish oil[J].Gut, 2003, 52 (1) ∶109-115.

[9]Ramos-De la Medina A, Remes-Troche JM, Roesch-Dietlen FB, et al.Routine liver biopsy to screen for nonalcoholic fatty liver disease (NAFLD) during cholecystectomy for gallstone disease:is it justified[J].J Gastrointest Surg, 2008, 12 (12) ∶20972102.

[10]Roesch-Dietlen F, Pérez-Morales A, Melo-Santisteban G, et al.Frequency and clinical, biochemical and histological characteristics of nonalcoholic fatty liver disease in patients with gallstone disease[J].Cir Cir, 2008, 76 (1) ∶37-42.

[11]Méndez-Sánchez N, Bermejo-Martínez LB, Viňals Y, et al.Serum leptin levels and insulin resistance are associated with gallstone disease in overweight subjects[J].World J Gastroenterol, 2005, 11 (39) ∶6182-6187.

[12]Olokoba AB, Bojuwoye BJ, Olokoba AB, et al.Gallstone disease and type-2diabetes mellitus-the link[J].J Coll Physicians Surg Pak, 2007, 17 (10) ∶594-597.

[13]Tsai CJ, Leitzmann MF, Willett WC, et al.Prospective study of abdominal adiposity and gallstones in US men[J].Am J Clin Nutr, 2004, 80 (1) ∶938-944.

施引文献

资源附件(0)

访问统计