1293例原发性肝癌患者非酒精性脂肪性肝病的伴发率及预后特征

刘晓燕; 李胜棉; 杨俭

1293例原发性肝癌患者非酒精性脂肪性肝病的伴发率及预后特征

河北医科大学附属第四医院消化内科

基金项目:

河北省科技攻关课题(042761106)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2010-06-20

The incidence and prognosis of non-alcoholic fatty liver disease in primary liver cancer 1293 cases

Research funding:

摘要

摘要: 目的回顾1293例原发性肝癌的临床资料,分析NAFLD伴发原发性肝癌的比例,探讨NAFLD作为可能病因的原发性肝癌的预后特征。方法建立原发性肝癌资料库。选出符合NAFLD诊断的病例75例,分析NAFLD相关的肝癌在原发性肝癌中所占的比例,同时对可能影响预后的指标进行分析。结果NAFLD伴发原发性肝癌的病例共75例,占原发性肝癌的5.8%。75例获得随访患者中死亡42例,1、2、3年总的生存率分别为60.55%、38.63%、29.53%。单因素分析显示:BMI、2型糖尿病、ALT、TBil/DBil、GGT、CHE因素,生存率差异比较有统计学意义(P<0.05)。多因素分析显示,BMI是影响预后的唯一的独立因素(χ2=5.766,P=0.016)。结论 NAFLD是原发性肝癌发生的可能原因之一。肥胖、2型糖尿病可能是影响NAFLD相关的原发性肝癌患者预后的危险因素,BMI增高者预后差。
- 脂肪肝 /
- 肝肿瘤 /
- 危险因素 /
- 预后
Abstract: Objective To analyze the clinical data of 1293 primary liver cancer cases and the NAFLD-related primary liver cancer in order to explore the prognosis of primary liver cancer caused by NAFLD retrospectively.Methods The data of primary liver cancer (PHC) cases were assessed and 75 cases of NAFLD were selected.The incidence of NAFLD-related liver cancer and the indicators that may affect the prognosis were analyzed.Results From the 75 NAFLD cases of 5.8% were with PHC and 42 cases PHC with NAFLD died during the follow-up.The overall 1, 2, and 3-year survival rates were 60.55%, 38.63% and 29.53%, respectively.BMI, Type 2 Diabetes, ALT, TBil /DBil, GGT and CHE had an influence on the survival rate (P < 0.05) .BMI was the only independent prognostic factor (χ2 = 5.766, P = 0.016) .Conclusion NAFLD may induce PHC.Obesity and Type 2 Diabetes could be the risk prognostic factors of NAFLD-related hepatocellular carcinoma.Patients with high BMI have poor prognosis.
- fatty liver /
- liver neoplasms /
- risk factors /
- prognosis

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参考文献(8)

[1]中华医学会.非酒精性脂肪肝性肝病诊断标准[J].中华肝脏病杂志, 2003, 11 (2) ∶71.

[2]Elisabetta B, Nicola L, EsterV, et al.Expanding the natural history of nonalcoholic steatoheptitis:From cryptogenic cirrhosis to hepatocellular careinoma[J].Gastroenterology, 2003, 123 (1) ∶134143.

[3]Hashimoto E, Taniai M, Kaneda H, et al.Comparison of hepatocellular carcinoma patients with alcoholic liver disease and nonalcoholic steatohepatitis[J].Alcohol Clin Exp Res, 2004, 28 (Suppl8) ∶164S-168S.

[4]Yoshioka Y, Hashimoto E, Yatsuji S, et al.Nonalcoholicsteatohepatitis:cirrhosis, hepatocellular carcinoma, and burnt-out NASH[J].Gastroenterol, 2004, 39 (12) ∶1215-1218.

[5]Caldwell SH, Crespo DM, Kang HS, et al.Obesity and hepatocellular carcinoma[J].Gastroenterology, 2004, 127 (5Suppl1) ∶S97103.

[6]Bugianesi E, Leone N, Vanni E, et al.Expanding the natural history of nonalcoholic steatohepatitis:from cryptogenic cirrhosis to hepatocellular carcinoma[J].Gastroenterology, 2002, 123 (1) ∶134140.

[7]Nair S, Mason A, Eason J.Is obesity an independent risk factor for hepatocellular carcinoma in cirrhosis[J].Hepatology, 2002, 36 (1) ∶150-155.

[8]Ipekci SH, Basaranoglu M, Sonsuz A.The fluctuation of serum levels of aminotransferase in patients with nonalcoholic steatohepatitis[J].J Clin Gastroenterol, 2003, 36 (4) ∶371.

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