PDF下载 ( 1186 KB)
The computational simulation development of bioreactor design optimization in bioartificial liver system
-
摘要: 肝衰竭是一种病死率可高达80%的严重疾病。过去的几十年中,研究者们已经研发了多种可提供肝衰竭病人暂时肝功能支持的人工肝系统(BAL)。生物反应器是生物人工肝的核心部件,其中有着许多复杂的流体动力学问题。近年来,随着计算机技术的快速发展,基于计算机的流体动力学仿真被用于生物人工肝研究并取得了令人瞩目的成绩。仿真研究为生物反应器的进一步优化设计提供了条件。本文就计算机仿真在生物反应器优化设计中的关键问题进行了详细综述。Abstract: Liver failure is a serious disease of which mortality rate is up to 80%.During the past decades, several attempts have been made to develop bioartificial liver systems (BAL) to provide temporary hepatic support to patients with liver failure.The bio-reactor is the core of the bio-artificial liver system, which exists within the complex fluid dynamics problems.In recent years, with the rapid development of computer technology, computer-based simulation of fluid dynamics on the bio-artificial liver has been developed rapidly and achieved gratifying achievements, which provide a good condition to further optimize the bio-artificial liver reactor.In this article, important aspects of the application of computational simulation technology in bioreactor design are summarized and an overview of the critical issues in the development of bioartificial liver devices is discussed.
-
Key words:
- liver /
- artificial
-
[1]Bartolo LD, Bader A. Development of a hybrid liver-support device[J]. Minim Invasive Ther Allied Technol, 2002, 11 (3) ∶123-134. [2]Lawrence BJ, Devarapalli M, Madihally SV. Flow dynamics in bioreactors containing tissue engineering scaffolds[J]. Biotechnol Bioeng, 2008, 102 (3) ∶935-947. [3] Van Ransbeeck P, Maes F, Impens S, et al. Numerical modeling of perfusion flow in irregular scaffolds[J]. IFMBE Proceedings, 2008, 22∶2677-2680. [4]Toh YC, Zhang C, Zhang J, et al. A novel 3D mammalian cell perfusion-culture system in microfluidic channels[J]. Lab Chip, 2007, 7 (3) ∶302-309. [5]Boschetti F, Raimondi MT, Migliavacca F, et al. Prediction of the micro-fluid dynamic environment imposed to three-dimensional engineered cell systems in bioreactors[J]. J Biomech, 2006, 39 (3) ∶418-425. [6] Leo HL, Xia L, Ng SS, et al. Computational fluid dynamics investigation of the effect of the fluid-induced shear stress on hepatocyte sandwich perfusion culture[J]. IFMBE Proceedings 2009, 23∶1405-1408. [7]Mareels G, Poyck PP, Eloot S, et al. Three-dimensional numerical modeling and computational fluid dynamics simulations to analyze and improve oxygen availability in the AMC bioartificial liver[J]. Ann Biomed Eng, 2006, 34 (11) ∶1729-1744. [8]Consolo F, Fiore GB, Truscello S, et al. A computational model for the optimization of transport phenomena in a rotating hollow-fiber bioreactor for artificial liver[J]. Tissue Eng Part C Methods, 2009, 15 (1) ∶41-55. [9]Niu M, Shi GB, Coger RN.A novel bioreactor engineered with mass transport and storage as key design specifications[C].Proceedings of the ASME2008Summer Bioengineering Conference. -
本文二维码
计量
- 文章访问数: 4628
- HTML全文浏览量: 14
- PDF下载量: 913
- 被引次数: 0
下载:
