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The significance of serum Anti-nuclear antibody level in Hepatitis B patients
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摘要: 目的观察不同病程的乙肝患者血清中ANA的表达及其与肝功能、HBVDNA的关系。方法对35例乙肝携带1患者、192例慢性乙肝患者,35例乙肝肝硬化患者检测血清中的ANA、肝功能、HBVDNA,并进行统计学分析。结果1.ANA在乙肝携带、慢性乙肝及乙肝肝硬化患者的血清中呈进行性升高趋势。2.192例患者中ANA阳性者共29例占15.10%,29例ANA阳性患者的ALT、TBil、ALB及HBVDNA较163例ANA阴性患者的均有升高,两者间差异有统计学意义(P<0.05)。结论ANA与乙肝患者的病程相关,并与HBVDNA复制水平及肝功能损伤的程度相关。Abstract: Objective To study the relationship between serum antinuclear antibody (ANA) , liver function tests and HBVDNA during the different course of hepatitis B virus (HBV) infection.Methods 35 HBV carriers, 192 chronic hepatitis B (CHB) and 35 post-hepatitis B cirrhosis patients were included in the study.The ANA, liver function tests, and HBVDNA were measured.Results ANA was gradually increased in HBV carriers, chronic hepatitis B and cirrhosis patients.From 192 CHB patients, 29 (15.1%) were ANA positive.The levels of ALT, TB, ALB and HBVDNA were significantly higher in ANA positives than ANA negative patients (P<0.05) .Conclusion The serum level of ANA is correlated with disease course, HBVDNA replication and the degree of liver damage.
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Key words:
- anti-nuclear antibodies /
- hepatitis B /
- HBVDNA /
- liver function test
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[1]Anna LZ, Alessia P, Carlo G.HBVand HCVchronic infection:Auto-immune manifestations and lymphoproliferation[J].Autoimmunity Reviews, 2008, 8 (2) :107-111. [2]Patrice C, David S, Marc B, et al.Hepatitis B virus genotypes and extrahepaticmanifestations[J].J Hepatology, 2005, 43 (5) :764-770. [3]陈瀑, 唐红, 宗华.乙型肝炎患者血清自身抗体检测研究[J].现代检验医学杂志, 2004, 19 (1) :25-26. [4]李晓良, 杨大国, 林巧, 等.1335例慢性乙型肝炎患者血清自身抗体检测分析[J].中西医结合肝病杂志, 2006, 16 (3) :162-163. [5] 中华医学会.病毒性肝炎防治方案[J].中华肝病杂志, 2000, 8 (5) :324-329. [6]Naparstek Y, Plotz PH.The role of autoantibodies in autoimmune disease[J].ANNu Rev immunol, 1993, 11:79-104. [7]刘胜勇, 张冬平, 李学军.抗平滑肌抗体、抗核抗体与慢性乙肝肝纤维化程度相关性研究[J].中国现代医生, 2008, 46 (3) :8-9. -
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