非酒精性脂肪性肝病(NAFLD):机遇与挑战

曾民德

非酒精性脂肪性肝病(NAFLD):机遇与挑战

曾民德

上海交通大学医学院附属仁济医院上海市消化疾病研究所,上海市脂肪性肝病诊治研究中心

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中图分类号: R575
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出版历程
- 出版日期: 2010-02-20

Nonalcoholic fatty liver disease (NAFLD): opportunities and challenges

Ceng MinDe

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参考文献(34)

[1]Williams R.Global challenges in liver disease[J].Hepatology, 2006, 44 (3) :521-526.

[2]Rustgi VK, Davis GL, Herrine SK.Future trends in hepatology:challenges and opportunities[J].Hepatology, 2008, 48 (2) :655-661.

[3]Ludwig J, Niggiano TR, McGill DB.et al.Nonalcoholic steatohepa-titis:Mayo Clinic experiences with a hitherto unnamed disease[J].Mayo Clin Proc, 1980, 55 (7) :434-438.

[4]Cassiman D, Jaeken J.NASHmay be trash[J].Gut, 2008, 57 (2) :141-144.

[5]Brunt EM.What's in a NAme[J].Hepatology, 2009, 50 (3) :663-667.

[6]Cortez-Pinto H, de Moura MC, Day CP.Non-alcoholic steatohep-atitis:from cell biology to clinical practice[J].J Hepatol, 2006, 44 (1) :197-208.

[7]Fabbrini E, Sullivan S.Hlein S.Obesity and Nonalcoholic Fatty Liver Disease:Biochemical, Metabolic and clinical Implications[J].Hep-atology, 2010, 51 (2) :679-689.

[8]曾民德.非酒精性脂肪性肝病研究的关切点[J].肝脏, 2009, 14 (4) :321-324.

[9]Ratziu V, Poynard T.Assessing the outcome of nonalcoholic steato-hepatitis-It's time to get serious[J].Hepatology, 2006, 44 (4) :802-805.

[10]Bugianesi E, McCullough AJ, Marchesini G.Insulin resistance:a metabolic pathway to chronic liver disease[J].Hepatology, 2005, 42 (5) :987-1000.

[11]McClain CJ, Barve S, Deaciuc I.Good fat/bad fat.Hepatology.2007, 45 (6) :1343-1346.

[12]Hotamisligil GS.Inflammation and metabolic disorders[J].Nature, 2006, 444 (7121) :860-867.

[13]Wellen KE, Hotamisligil GS.Obesity-induced inflammatory chan-ges in adipose tissue[J].J Clin Invest, 2003, 112 (12) :1785-1788.

[14]van der Poorten D, Milner KL, Hui J, et al.Visceral fat:a key me-diator of steatohepatitis in metabolic liver disease[J].Hepatology, 2008, 48 (2) :449-457.

[15]Vega GL, Chandalia M, Szczepaniak LS, et al.Metabolic correlates of nonalcoholic fatty liver in women and men[J].Hepatology, 2007, 46 (3) :716-722.

[16]Maher JJ, Leon P, Ryan JC.Beyond insulin resistance:Innate im-munity in nonalcoholic steatohepatitis[J].Hepatology, 2008, 48 (2) :670-678.

[17] 曾民德.脂肪性肝病与脂肪组织失调[J].国外医学消化分册, 2003, 23 (Suppl1) :20-22.

[18]Smith B, George J.Adipocyte-hepatocyte crosstalk and the patho-genesis of nonalcoholic fatty liver disease[J].Hepatology, 2009, 49 (5) :1765-1767.

[19]Kodama Y, Brenner DA.C-Jun N-terminal kinase signaling in the pathogenesis of nonalcoholic fatty liver disease:Multiple roles in multiple steps[J].Hepatology, 2009, 49 (1) :6-8.

[20]Pena AD, Leclercq I, Field J, et al.NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis[J].Gastroenterology, 2005, 129 (5) :1663-1674.

[21]Day CP.From fat to inflammation[J].Gastroenterology, 2006, 130 (1) :207-210.

[22]Elsharkawy AM, Mann DA.Nuclear factor-kappaB and the hepat-ic inflammation-fibrosis-cancer axis[J].Hepatology, 2007, 46 (2) :590-597.

[23]Lonardo A, Lombardini S, Scaglioni F, et al.Hepatic steatosis and insulin resistance:does etiology make a difference-[J]J Hepatol, 2006, 44 (1) :190-196.

[24]Berk PD.Regulatable fatty acid transport mechanisms are central to the pathophysiology of obesity, fatty liver, and metabolic syndrome[J].Hepatology, 2008, 48 (5) :1362-1376.

[25]Cali AM, De Oliveira AM, KimH, et al.Glucose dysregulation and hepatic steatosis in obese adolescents:is there a link-[J]Hepatol-ogy, 2009, 49 (6) :1896-1903.

[26]Vos B, Moreno C, Nagy N, et al.Non Obese, Non Diabetic Fatients Pvesenting with Nonalcoholic Fatty liver Disease:An Expandable Clinico-Pathological Entity[J].J Hepatol, 2009, 50:S373.

[27]Vanni E, Abate ML, Gentilcore E, et al.Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients with chronic hepatitis C[J].Hepatology, 2009, 50 (3) :697-706.

[28]Croswell JM, Kramer BS.Clinical trial design and evidence-based outcomes in the study of liver diseases[J].J Hepatol, 2009, 50 (4) :817-826.

[29]Ong JP, Pitts A, Younossi ZM.Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease[J].J Hepatol, 2008, 49 (4) :608-612.

[30]Ekstedt M, Franzn LE, Mathiesen UL, et al.Long-term follow-up of patients with NAFLD and elevated liver enzymes[J].Hepatol-ogy, 2006, 44 (4) :565-573.

[31]曾民德.非酒精性脂肪性肝病 (NAFLD) 的临床评价[J].肝脏, 2009, 14 (5) :409-412.

[32]David K, Kowdley KV, Unalp A, et al.Quality of life in adults with nonalcoholic fatty liver disease:baseline data from the nonalco-holic steatohepatitis clinical research network[J].Hepatology, 2009, 49 (6) :1904-1912.

[33]Dan AA, Kallman JB, Wheeler A, et al.Health-related quality of life in patients with non-alcoholic fatty liver disease[J].Ali-ment Pharmacol Ther, 2007, 26 (6) :815-820.

[34]Afendy A, Kallman JB, Stepanova M, et al.Predictors of health-related quality of life in patients with chronic liver disease[J].Ali-ment Pharmacol Ther, 2009, 30 (5) :469-476.

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