替比夫定联合酚妥拉明治疗慢性乙型重型肝炎的临床研究

张薇薇; 袁学华; 谭华炳; 占国清; 李儒贵; 杜卫星

替比夫定联合酚妥拉明治疗慢性乙型重型肝炎的临床研究

1. 郧阳医学院附属人民医院感染科
2. 十堰市妇幼保健院检验科

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中图分类号: R512.62
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出版历程
- 出版日期: 2009-06-20

Therapeutic Efficacy of telbivudine with phentolamine on patients with chronic severe hepatits B

摘要

摘要: 目的研究替比夫定联合酚妥拉明治疗慢性乙型重型肝炎的疗效。方法将60例患者随机分为两组,治疗组30例,采用替比夫定联合酚妥拉明治疗;对照组30例,静点茵栀黄注射液。两组均予以支持对症治疗。观察两组TBil(血清总胆红素),PTA(凝血酶原活动度),HBVDNA变化情况。结果治疗4周,治疗组在TBil降低的程度上与对照组比较差异有统计学意义(P<0.05)。治疗6周,治疗组在升高PTA值与对照组比较有统计学意义(P<0.05)。且治疗组临床疗效明显优于对照组,治疗6周临床总有效率达70%。治疗组在HBVDNA定量下降≥1log10copies/mL与对照组比较有统计学意义(P<0.05)。结论替比夫定联合酚妥拉明治疗对慢性重型肝炎TBil降低、PTA值升高、HBVDNA定量下降有较好疗效。
- 替比夫定 /
- 酚妥拉明 /
- 重型肝炎 /
- 治疗学
Abstract: Objective To study the efficacy of telbivudine combined with phentolamine on chronic severe hepatits B patients.Methods 60 patients were randomly divided into two groups.The treatment group (n=30) were treated with telbivudine and phentolamine, while the control group (n=30) were treated with Yinzhihuang.Additionally, both groups were given supportive symptomatic therapy.Serum total bilirubin (TBIL) , PTA and HBV DNA were analyzed.Results TBIL in treatment group was decreased significantly after 4 weeks of therapy (p<0.05) .PTA and clinical conditions of the patients in the treatment group were significantly improved after 6 weeks of treatment (p<0.05) .The total treatment efficacy was found to be 70%.The level of HBV DNA in treatment group was significantly decreased compared with that of the control group (p<0.05) .Conclusion Telbivudine combined with phentolamine has a better effect on chronic severe hepatitis B patients.
- telbivudine /
- phentolamine /
- severe hepatitis /
- therapy

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