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终末期肝病模型及Child-Pugh分级对失代偿期肝硬化患者的预后分析

占国清 郑三菊 朱琳 王崇慧 李金科 张薇薇

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终末期肝病模型及Child-Pugh分级对失代偿期肝硬化患者的预后分析

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  • 中图分类号: R575.2

The analysis of prognosis of patients with decompensated liver cirrhosis using the criterion of the model for end-stage liver disease and Child-Pugh grading

  • 摘要: 目的探讨终末期肝病模型(MELD)及Child-Pugh评分对失代偿期肝硬化预后评估的应用价值。方法应用MELD评分公式及Child-Pugh分级对136例失代偿期肝硬化患者进行评分及分级,比较两种系统对肝硬化预后的评估。结果分别有19.85%和33.82%患者3个月和6个月内死亡,死亡组MELD和Child-Pugh评分均高于生存组(P<0.001);MELD评分在3个月预后评估的ROC曲线AUC高于Child-Pugh评分(P<0.05);生存分析表明MELD与Child-Pugh评分均可有效地分辨6个月内可能生存及死亡的患者(P<0.005);MELD评分与Child评分显著相关(r=0.67,P<0.001)。结论MELD评分及Child-Pugh评分均可预测失代偿期肝硬化患者短期预后,MELD评分短期评估优于Child-Pugh分级。

     

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  • 出版日期:  2009-02-20
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